FGFR4

Gene Symbol	FGFR4
Entrez Gene	2264
Alt Symbol	CD334, JTK2, TKF
Species	Human
Gene Type	protein-coding
Description	fibroblast growth factor receptor 4
Other Description	hydroxyaryl-protein kinase|protein-tyrosine kinase|tyrosine kinase related to fibroblast growth factor receptor|tyrosylprotein kinase
Swissprots	P22455 Q96KE5 Q71TW8 O43785 Q8TDA0 G3JVM9 G3JVM2 G3JVM7 G3JVM5 Q14309
Accessions	AAB25788 AAM13666 ABQ01235 CAA74200 CAB75718 EAW85034 EAW85035 EAW85036 EAW85037 P22455 AB209631 BAD92868 AF202063 AAF27432 AF359241 AAK43714 AF359246 AAK51435 AK225280 AK225909 AK301169 BAG62757 BC011847 AAH11847 BF307233 BM453707 DQ893458 ABM84384 DQ896348 ABM87347 EU826602 ACF47638 EU826603 ACF47639 JN007471 AEO19712 JN007472 AEO19713 JN007473 AEO19714 JN007474 AEO19715 JN007475 AEO19716 JN007476 AEO19717 JN007477 AEO19718 JN007478 AEO19719 JN007479 AEO19720 JN007480 AEO19721 JN007481 AEO19722 JN007482 AEO19723 L03840 AAB59389 M59373 AAA63208 X57205 CAA40490 XM_005265838 XP_005265895 XM_011534464 XP_011532766 XM_011534465 XP_011532767 XR_941090 NM_001291980 NP_001278909 NM_002011 NP_002002 NM_022963 NP_075252 NM_213647 NP_998812
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is
Subcellular Location	Isoform 3: Cytoplasm {ECO:0000269|PubMed:11781352}.
Tissue Specificity	Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines. {ECO:0000269|PubMed:10631118}.
Top Pathways	MAPK signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FGFR4 overexpression lysate - LY400735 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

FGFR4 overexpression lysate - LY403876 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

FGFR4 overexpression lysate - LY429711 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

FGFR4 overexpression lysate - LY431021 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

FGFR4 293 Cell Lysate - 400712 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

FGF R4 Overexpression Lysate (Native) - NBP2-06375 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

FGF R4 Overexpression Lysate (Native) - NBL1-10707 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

FGFR4 Over-expression Lysate Product - GWB-FC2646 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Rhesus FGFR4 / FGF Receptor 4 HEK293 Cell Lysate (WB positive control) - 90134-C08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Rhesus

Rhesus FGFR4 / FGF Receptor 4 HEK293 Cell Lysate (WB positive control) - 90134-C02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Rhesus

Human FGFR4 / FGF Receptor 4 HEK293 Cell Lysate (WB positive control) - 10538-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human FGFR4 / FGF Receptor 4 HEK293 Cell Lysate (WB positive control) - 10538-H03HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human FGFR4 / FGF Receptor 4 HEK293 Cell Lysate (WB positive control) - 10538-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human FGFR4 Human Cells Transfected Lysate (positive control) (denatured) - orb172904 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

FGF R4 Overexpression Lysate (Native) - NBP2-04467 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

FGF R4 Overexpression Lysate (Native) - NBP2-09909 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

FGF R4 Overexpression Lysate (Native) - NBP2-10134 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Human FGFR4 Human Cells Transfected Lysate (positive control) (denatured) - orb173824 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human FGFR4 Human Cells Transfected Lysate (positive control) (denatured) - orb172905 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

FGFR4-knockout Cell lysate - LC810080 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human FGFR4 Knockdown Stable Cell Line - CSC-DC005723 from Creative biogene Category Cell Line Species Human

Human FGFR4 Knockout Cell Line-HeLa - CSC-RT0699 from Creative biogene Category Cell Line Species Human

FGFR4 KO Cell Lysate-HeLa - CLKO-0204 from Creative biogene Category Cell Lysate

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