FGFR4

Gene Symbol	FGFR4
Entrez Gene	2264
Alt Symbol	CD334, JTK2, TKF
Species	Human
Gene Type	protein-coding
Description	fibroblast growth factor receptor 4
Other Description	hydroxyaryl-protein kinase|protein-tyrosine kinase|tyrosine kinase related to fibroblast growth factor receptor|tyrosylprotein kinase
Swissprots	P22455 Q96KE5 Q71TW8 O43785 Q8TDA0 G3JVM9 G3JVM2 G3JVM7 G3JVM5 Q14309
Accessions	AAB25788 AAM13666 ABQ01235 CAA74200 CAB75718 EAW85034 EAW85035 EAW85036 EAW85037 P22455 AB209631 BAD92868 AF202063 AAF27432 AF359241 AAK43714 AF359246 AAK51435 AK225280 AK225909 AK301169 BAG62757 BC011847 AAH11847 BF307233 BM453707 DQ893458 ABM84384 DQ896348 ABM87347 EU826602 ACF47638 EU826603 ACF47639 JN007471 AEO19712 JN007472 AEO19713 JN007473 AEO19714 JN007474 AEO19715 JN007475 AEO19716 JN007476 AEO19717 JN007477 AEO19718 JN007478 AEO19719 JN007479 AEO19720 JN007480 AEO19721 JN007481 AEO19722 JN007482 AEO19723 L03840 AAB59389 M59373 AAA63208 X57205 CAA40490 XM_005265838 XP_005265895 XM_011534464 XP_011532766 XM_011534465 XP_011532767 XR_941090 NM_001291980 NP_001278909 NM_002011 NP_002002 NM_022963 NP_075252 NM_213647 NP_998812
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is
Subcellular Location	Isoform 3: Cytoplasm {ECO:0000269|PubMed:11781352}.
Tissue Specificity	Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines. {ECO:0000269|PubMed:10631118}.
Top Pathways	MAPK signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human FGFR4 protein fragment - ab135023 from Abcam Category Protein Prices $465.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human FGFR4 protein fragment - ab89754 from Abcam Category Protein Prices $302.00, $352.00, $1,845.00 Sizes 5 µg, 10 µg, 100 µg Source Insect cells Species Human

Active human FGFR4 protein fragment - ab167751 from Abcam Category Protein Prices $465.00 Sizes 200 µg Source HEK 293 cells Species Human

Human FGFR4 full length protein - ab131981 from Abcam Category Protein Source Wheat germ Species Human

Human FGFR4 peptide - ab42267 from Abcam Category Peptide

Human FGFR4 protein fragment - ab152386 from Abcam Category Protein Source Wheat germ Species Human

Human FGFR4 protein fragment - ab55761 from Abcam Category Protein Source Insect cells Species Human

FGFR4 protein (Fc Chimera) - ab83999 from Abcam Category Protein Source HEK 293 cells Species Human

FGFR4 Antibody Blocking Peptide - LS-E9141 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FGF R4 Recombinant Protein - H00002264-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 25 ug 10 ug Species Human

FGF R4 Partial Recombinant Protein - H00002264-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

FGF R4 Recombinant Protein - P4693 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

FGF R4 Recombinant Protein - H00002264-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

FGF R4 Peptide - P2667 from Novus Biologicals Category Peptide Species Human

FGFR4-Antibody-N-term-Blocking-Peptide - BP7639a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human FGF R4 Fc Chimera, CF - 685-FR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human Fibroblast Growth Factor Receptor-4 Protein (OPPA01146) - OPPA01146 from Aviva Systems Biology Category Protein Prices $160.00 Sizes 10 µg Source Insect Cells Species Human

Mouse CD334 protein - orb83226 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Mouse Species Human

Human CD334 protein - orb83002 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Cynomolgus CD334 protein - orb138871 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells

Human CD334 protein - orb83003 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Cynomolgus CD334 protein - orb138872 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells

Human CD334 protein - orb84427 from Biorbyt Category Protein Prices $434.00, $646.00 Sizes 50 μg, 100 μg Source Human Species Human

Human FGFR4 Enzyme - orb191392 from Biorbyt Category Protein Prices $170.00, $315.00 Sizes 2 μg, 10 μg Source Insect Cells. Species Human

FGFR4 Blocking Peptide - abx161101 from Abbexa Category Peptide Species Human, Mouse, Rat, Rabbit

Search more