FGFR4

Gene Symbol	FGFR4
Entrez Gene	2264
Alt Symbol	CD334, JTK2, TKF
Species	Human
Gene Type	protein-coding
Description	fibroblast growth factor receptor 4
Other Description	hydroxyaryl-protein kinase|protein-tyrosine kinase|tyrosine kinase related to fibroblast growth factor receptor|tyrosylprotein kinase
Swissprots	P22455 Q96KE5 Q71TW8 O43785 Q8TDA0 G3JVM9 G3JVM2 G3JVM7 G3JVM5 Q14309
Accessions	AAB25788 AAM13666 ABQ01235 CAA74200 CAB75718 EAW85034 EAW85035 EAW85036 EAW85037 P22455 AB209631 BAD92868 AF202063 AAF27432 AF359241 AAK43714 AF359246 AAK51435 AK225280 AK225909 AK301169 BAG62757 BC011847 AAH11847 BF307233 BM453707 DQ893458 ABM84384 DQ896348 ABM87347 EU826602 ACF47638 EU826603 ACF47639 JN007471 AEO19712 JN007472 AEO19713 JN007473 AEO19714 JN007474 AEO19715 JN007475 AEO19716 JN007476 AEO19717 JN007477 AEO19718 JN007478 AEO19719 JN007479 AEO19720 JN007480 AEO19721 JN007481 AEO19722 JN007482 AEO19723 L03840 AAB59389 M59373 AAA63208 X57205 CAA40490 XM_005265838 XP_005265895 XM_011534464 XP_011532766 XM_011534465 XP_011532767 XR_941090 NM_001291980 NP_001278909 NM_002011 NP_002002 NM_022963 NP_075252 NM_213647 NP_998812
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is
Subcellular Location	Isoform 3: Cytoplasm {ECO:0000269|PubMed:11781352}.
Tissue Specificity	Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines. {ECO:0000269|PubMed:10631118}.
Top Pathways	MAPK signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® FGF Receptor 4 siRNA I - 12472 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® FGF Receptor 4 siRNA II - 12669 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

FGFR-4 CRISPR/Cas9 KO Plasmid (h) - sc-400399 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FGFR-4 HDR Plasmid (h) - sc-400399-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FGFR-4 Double Nickase Plasmid (h) - sc-400399-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FGFR-4 Double Nickase Plasmid (h2) - sc-400399-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FGFR-4 CRISPR Activation Plasmid (h) - sc-400399-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FGFR-4 CRISPR Activation Plasmid (h2) - sc-400399-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FGFR-4 Lentiviral Activation Particles (h) - sc-400399-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FGFR-4 Lentiviral Activation Particles (h2) - sc-400399-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FGFR-4 siRNA (h) - sc-35368 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FGFR-4 shRNA Plasmid (h) - sc-35368-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FGFR-4 shRNA (h) Lentiviral Particles - sc-35368-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FGF R4 RNAi - H00002264-R10 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU085491 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0783 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0784 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0785 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2588 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2588 from Sigma-Aldrich Category ZFN Kit

MISSION® 3′UTR Lenti GoClone™ - HUTR03884 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr03884

FGFR4 siRNA (Human) - CRH1584 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FGF R4 RNAi - H00002264-R11 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

FGF R4 RNAi - H00002264-R12 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

FGFR4 - MBS8211748 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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