| Gene Symbol |
NFATC2IP
|
| Entrez Gene |
84901
|
| Alt Symbol |
ESC2, NIP45, RAD60
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
|
| Other Description |
45 kDa NF-AT-interacting protein|45 kDa NFAT-interacting protein|NFATC2-interacting protein|nuclear factor of activated T-cells, cytoplasmic 2-interacting protein
|
| Swissprots |
Q8NFR2 Q6NVK1 Q8NCF5 Q66K34 B7Z4G5 Q96ST9
|
| Accessions |
CAF86795 EAW52014 EAW52015 Q8NCF5 AF458593 AAM49721 AK027545 BAB55189 AK074761 BAC11189 AK094764 AK297333 BAH12551 AK304172 BAH14125 AK304606 BAH14223 AK316535 BAH14906 AL043335 BC010161 BC018311 AAH18311 BC021551 AAH21551 BC068007 AAH68007 BC080628 AAH80628 BC101741 AAI01742 BC112182 AAI12183 XR_950864 NM_032815 NP_116204
|
| Function |
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'- methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus. {ECO:0000250}.
|