Gene Symbol | NFATC2IP |
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Entrez Gene | 84901 |
Alt Symbol | ESC2, NIP45, RAD60 |
Species | Human |
Gene Type | protein-coding |
Description | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein |
Other Description | 45 kDa NF-AT-interacting protein|45 kDa NFAT-interacting protein|NFATC2-interacting protein|nuclear factor of activated T-cells, cytoplasmic 2-interacting protein |
Swissprots | Q8NFR2 Q6NVK1 Q8NCF5 Q66K34 B7Z4G5 Q96ST9 |
Accessions | CAF86795 EAW52014 EAW52015 Q8NCF5 AF458593 AAM49721 AK027545 BAB55189 AK074761 BAC11189 AK094764 AK297333 BAH12551 AK304172 BAH14125 AK304606 BAH14223 AK316535 BAH14906 AL043335 BC010161 BC018311 AAH18311 BC021551 AAH21551 BC068007 AAH68007 BC080628 AAH80628 BC101741 AAI01742 BC112182 AAI12183 XR_950864 NM_032815 NP_116204 |
Function | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'- methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus. {ECO:0000250}. |
NFATc2IP CRISPR/Cas9 KO Plasmid (h) - sc-408302 from Santa Cruz Biotechnology
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NFATc2IP HDR Plasmid (h) - sc-408302-HDR from Santa Cruz Biotechnology
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NFATc2IP Double Nickase Plasmid (h) - sc-408302-NIC from Santa Cruz Biotechnology
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NFATc2IP Double Nickase Plasmid (h2) - sc-408302-NIC-2 from Santa Cruz Biotechnology
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NFATc2IP CRISPR Activation Plasmid (h) - sc-408302-ACT from Santa Cruz Biotechnology
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NFATc2IP CRISPR Activation Plasmid (h2) - sc-408302-ACT-2 from Santa Cruz Biotechnology
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NFATc2IP Lentiviral Activation Particles (h) - sc-408302-LAC from Santa Cruz Biotechnology
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NFATc2IP Lentiviral Activation Particles (h2) - sc-408302-LAC-2 from Santa Cruz Biotechnology
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NFATc2IP siRNA (h) - sc-93159 from Santa Cruz Biotechnology
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NFATc2IP shRNA Plasmid (h) - sc-93159-SH from Santa Cruz Biotechnology
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NFATc2IP shRNA (h) Lentiviral Particles - sc-93159-V from Santa Cruz Biotechnology
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NFATC2IP RNAi - H00084901-R01 from Novus Biologicals
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NFATC2IP RNAi - H00084901-R02 from Novus Biologicals
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MISSION® esiRNA - EHU042881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15240 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15240 from Sigma-Aldrich
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NFATC2IP siRNA (Human) - CRJ3679 from Cohesion Biosciences
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shRNA set against Human NFATC2IP (NM_032815.3) - SHH351728 from Creative biogene
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shRNA set against Human NFATC2IP(NM_032815.3) - SHR006518 from Creative biogene
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Human NFATC2IP siRNA - orb274180 from Biorbyt
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NFATC2IP shRNA Plasmid (Human) - CHJ3679 from Cohesion Biosciences
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NFATC2IP miRNA 3'UTR clone - MiUTR1H-06747 from Creative biogene
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