| Gene Symbol |
PPARD
|
| Entrez Gene |
5467
|
| Alt Symbol |
FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
peroxisome proliferator-activated receptor delta
|
| Other Description |
PPAR-beta|PPAR-delta|nuclear hormone receptor 1|nuclear receptor subfamily 1 group C member 2|peroxisome proliferator-activated nuclear receptor beta/delta variant 2|peroxisome proliferator-activated receptor beta
|
| Swissprots |
Q5D1P0 Q7Z5K0 E9PE18 Q03181 B6ZGS1 B4E3V3 A8K6J6 B7Z3W1 Q9BUD4
|
| Accessions |
AAF62553 AAR05439 CAD55573 CBX54351 EAX03825 EAX03826 EAX03827 EAX03828 Q03181 AB099507 BAC78903 AB307691 BAH02282 AK122614 BAG53624 AK291661 BAF84350 AK296425 BAH12347 AK304482 BAG65293 AK304878 BAG65615 AY919140 AAX14041 AY927506 BC002715 AAH02715 BC007578 AAH07578 BC127809 BE503383 BQ441091 CN332566 DA192442 DA476590 HQ692865 ADZ17376 L07592 AAA36469 XM_005249193 XP_005249250 XM_006715120 XP_006715183 XM_006715121 XP_006715184 XM_006715123 XP_006715186 XM_011514707 XP_011513009 XM_011514708 XP_011513010 XM_011514709 XP_011513011 XM_011514710 XP_011513012 XM_011514711 XP_011513013 XM_011514712 XP_011513014 XM_011514713 XP_011513015 NM_001171818 NP_001165289 NM_001171819 NP_001165290 NM_001171820 NP_001165291 NM_006238 NP_006229 NM_177435 NP_803184
|
| Function |
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. {ECO:0000269|PubMed:1333051, ECO:0000269|PubMed:15604518}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Ubiquitous with maximal levels in placenta and skeletal muscle.
|
| Top Pathways |
Wnt signaling pathway, Acute myeloid leukemia, PPAR signaling pathway
|
![Western Blot: PPAR delta Overexpression Lysate (Adult Normal) [NBL1-14632] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PPAR delta.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9296_PPAR%2520delta%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14632-img0002.jpg)