SORL1

Gene Symbol	SORL1
Entrez Gene	6653
Alt Symbol	C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250
Species	Human
Gene Type	protein-coding
Description	sortilin-related receptor, L(DLR class) A repeats containing
Other Description	LDLR relative with 11 ligand-binding repeats|low-density lipoprotein receptor relative with 11 ligand-binding repeats|mosaic protein LR11|sortilin-related receptor|sortilin-related receptor, L(DLR class) A repeats-containing|sorting protein-related receptor containing LDLR class A repeats
Swissprots	Q92673 B2RNX7 Q92856
Accessions	CCQ43198 EAW67524 EAW67525 EAW67526 EAW67527 Q92673 AI358248 AK025583 AK096577 AK294404 BAG57656 AK295090 BAG58131 AK295878 BAG58675 AK302589 BAG63842 AK309523 AK316340 BAH14711 BC032903 BC040643 BC137171 AAI37172 BQ888333 BX365721 DA386525 DB499706 DN831521 U90916 Y08110 CAA69325 XM_011542963 XP_011541265 XM_011542964 XP_011541266 XM_011542965 XP_011541267 XM_011542966 XP_011541268 XM_011542967 XP_011541269 NM_003105 NP_003096
Function	Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization. {ECO:0000269|PubMed:14764453, ECO:0000269|PubMed:16174740}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus. Endosome. Secreted.
Tissue Specificity	Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. Expression is significantly reduced in the frontal cortex of patients suffering from Alzheimer disease. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals. {ECO:0000269|PubMed:16174740}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Human SORL1 ELISA Kit (Sandwich ELISA) - LS-F12639 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Sortilin-related receptor (SORL1), Human, ELISA Kit - CSB-EL022411HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Sortilin-related receptor (SORL1), Human, ELISA Kit - E01S0392 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Sortilin-related receptor, SORL1, Human, ELISA Kit - E5512h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.156-10 ng/mL

Sortilin related receptor (SORL1), ELISA Kit - MBS7231943 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin-related receptor (SORL1), ELISA Kit - MBS7250473 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin-related receptor (SORL1), ELISA Kit - MBS7220567 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin-related receptor (SORL1), ELISA Kit - MBS7213656 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin-related receptor (SORL1), ELISA Kit - MBS7224952 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin-related receptor (SORL1), ELISA Kit - MBS7204261 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin-related receptor (SORL1), ELISA Kit - MBS7206832 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin-related receptor (SORL1), ELISA Kit - MBS7213781 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin-related receptor (SORL1), ELISA Kit - MBS7237629 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin-related receptor (SORL1), ELISA Kit - MBS7208958 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

sortilin-related receptor, L (DLR class) A repeats-containing, ELISA Kit - MBS906761 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human SORL1 is typically less than 0.039 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0.156 ng/ml -10 ng/ml.

Human Sortilin-related receptor(SORL1) ELISA kit - CSB-EL022411HU from Cusabio Category ELISA Kit Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Chicken SORL1 ELISA Kit (Custom ELISA) - LS-F19993 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse SORL1 ELISA Kit (Custom ELISA) - LS-F19992 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Rabbit SORL1 ELISA Kit - LS-F19991 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Human Sortilin-related receptor ELISA Kit - abx251671 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human Sortilin-related receptor (SORL1) ELISA Kit - EKC35636 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Human Sortilin-related receptor ELISA Kit - EKE54513 from Biomatik Category ELISA Kit Prices $759.00, $3,225.75, $6,072.00 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.052 ng/mL Range 0.156-10 ng/mL

SORL1 - EKH4636 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

SORL1 ELISA Kit (Human) : 96 Wells (OKEH01762) - OKEH01762 from Aviva Systems Biology Category ELISA Kit Prices $450.00 Sizes 96 wells Sensitivity < 0.052 ng/mL Range 0.156 - 10 ng/mL

Human SORL1 ELISA Kit - E036191 from Biobool Category ELISA Kit

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