SORL1

Gene Symbol	SORL1
Entrez Gene	6653
Alt Symbol	C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250
Species	Human
Gene Type	protein-coding
Description	sortilin-related receptor, L(DLR class) A repeats containing
Other Description	LDLR relative with 11 ligand-binding repeats|low-density lipoprotein receptor relative with 11 ligand-binding repeats|mosaic protein LR11|sortilin-related receptor|sortilin-related receptor, L(DLR class) A repeats-containing|sorting protein-related receptor containing LDLR class A repeats
Swissprots	Q92673 B2RNX7 Q92856
Accessions	CCQ43198 EAW67524 EAW67525 EAW67526 EAW67527 Q92673 AI358248 AK025583 AK096577 AK294404 BAG57656 AK295090 BAG58131 AK295878 BAG58675 AK302589 BAG63842 AK309523 AK316340 BAH14711 BC032903 BC040643 BC137171 AAI37172 BQ888333 BX365721 DA386525 DB499706 DN831521 U90916 Y08110 CAA69325 XM_011542963 XP_011541265 XM_011542964 XP_011541266 XM_011542965 XP_011541267 XM_011542966 XP_011541268 XM_011542967 XP_011541269 NM_003105 NP_003096
Function	Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization. {ECO:0000269|PubMed:14764453, ECO:0000269|PubMed:16174740}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus. Endosome. Secreted.
Tissue Specificity	Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. Expression is significantly reduced in the frontal cortex of patients suffering from Alzheimer disease. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals. {ECO:0000269|PubMed:16174740}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

SorLA (7D7B11) - sc-101426 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SorLA (H-300) - sc-33822 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

SorLA (D-18) - sc-34155 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SorLA (E-15) - sc-34154 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SorLA (P-18) - sc-34152 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SorLA (48) - sc-136073 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Anti-SorLA antibody - ab16642 from Abcam Prices $388.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SorLA antibody - ab22814 from Abcam Prices $376.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-SorLA antibody [3B6B11] - ab63336 from Abcam Prices $387.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3B6B11

Anti-SorLA antibody [7D7B11] - ab63573 from Abcam Host Mouse Clonality Monoclonal Clone 7D7B11

Anti-SorLA antibody [EPR14670] - ab190684 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14670

Anti-SORL1 Antibody IHC-plus™ - LS-B3464 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Mouse Clonality Monoclonal

Anti-SORL1 Antibody (C-Terminus) - LS-C94863 from LifeSpan Bioscience Prices $325.00 Sizes 500 µg Host Rabbit Clonality Polyclonal

Anti-SORL1 Antibody - LS-C144189 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Anti-SORL1 Antibody (aa2177-2214) - LS-C184124 from LifeSpan Bioscience Prices $530.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SORL1 Antibody (aa2177-2214) - LS-C184125 from LifeSpan Bioscience Prices $530.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SORL1 Antibody (aa2159-2214) - LS-C41515 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-SORL1 Antibody (aa2177-2214, Biotin) - LS-C184126 from LifeSpan Bioscience Prices $605.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SORL1 Antibody (aa2177-2214, CF) - LS-C184127 from LifeSpan Bioscience Prices $605.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SORL1 Antibody (aa2177-2214, FITC) - LS-C184128 from LifeSpan Bioscience Prices $605.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SORL1 Antibody (aa2177-2214, Rhodamine) - LS-C184129 from LifeSpan Bioscience Prices $605.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SORL1 Antibody (aa2203-2214) - LS-C55512 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-SORL1 Antibody (clone 3F2) - LS-C198242 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3F2

SorLA Antibody [Unconjugated] - AF5699 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

SorLA Antibody (3B6B11) - NBP1-28882 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3B6B11

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