SORL1

Gene Symbol	SORL1
Entrez Gene	6653
Alt Symbol	C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250
Species	Human
Gene Type	protein-coding
Description	sortilin-related receptor, L(DLR class) A repeats containing
Other Description	LDLR relative with 11 ligand-binding repeats|low-density lipoprotein receptor relative with 11 ligand-binding repeats|mosaic protein LR11|sortilin-related receptor|sortilin-related receptor, L(DLR class) A repeats-containing|sorting protein-related receptor containing LDLR class A repeats
Swissprots	Q92673 B2RNX7 Q92856
Accessions	CCQ43198 EAW67524 EAW67525 EAW67526 EAW67527 Q92673 AI358248 AK025583 AK096577 AK294404 BAG57656 AK295090 BAG58131 AK295878 BAG58675 AK302589 BAG63842 AK309523 AK316340 BAH14711 BC032903 BC040643 BC137171 AAI37172 BQ888333 BX365721 DA386525 DB499706 DN831521 U90916 Y08110 CAA69325 XM_011542963 XP_011541265 XM_011542964 XP_011541266 XM_011542965 XP_011541267 XM_011542966 XP_011541268 XM_011542967 XP_011541269 NM_003105 NP_003096
Function	Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization. {ECO:0000269|PubMed:14764453, ECO:0000269|PubMed:16174740}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus. Endosome. Secreted.
Tissue Specificity	Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. Expression is significantly reduced in the frontal cortex of patients suffering from Alzheimer disease. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals. {ECO:0000269|PubMed:16174740}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Human SorLA peptide - ab16691 from Abcam Category Peptide

Human SorLA peptide - ab45436 from Abcam Category Peptide Species Human

Human SorLA protein fragment - ab114683 from Abcam Category Protein Source Wheat germ Species Human

SORL1 Antibody Blocking Peptide - LS-E25207 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SorLA Protein - H00006653-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SorLA (C Terminus) blocking peptide - GTX89685-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

SorLA (internal) blocking peptide - GTX89100-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

SorLA Peptide - AC21-0028-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Sortilin-related receptor (SORL1) - H00006653-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Sortilin-related receptor (SORL1) - H00006653-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Sortilin-related receptor (SORL1) control peptide - AP10329CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

SORL1 Peptide - 46-418P from ProSci Category Peptide Species Mouse

SORL1 fusion protein - ag18277 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SORL1 fusion protein - Ag18445 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human SORL1 - SORL1-29617TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Sortilin-related receptor(SORL1) ,partial - CSB-YP821688HU CSB-EP821688HU CSB-BP821688HU CSB-MP821688HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SORL1 / LR11 (C Terminus), Peptide - MBS425163 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Mouse, Rat, Dog, Bovine

SORL1/LR11, Peptide - MBS428334 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

SorLA Recombinant Protein Antigen - NBP2-38177PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Sortilin-related receptor (SORL1), partial, Recombinant Protein - MBS1476644 from MyBioSource Category Protein Prices $970.00, $970.00, $1,190.00, $1,190.00, $1,430.00, $1,430.00, $1,890.00, $1,890.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SORL1 Immunizing peptide - orb16736 from Biorbyt Category Peptide

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