| Gene Symbol |
TNFRSF13B
|
| Entrez Gene |
23495
|
| Alt Symbol |
CD267, CVID, CVID2, IGAD2, RYZN, TACI, TNFRSF14B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tumor necrosis factor receptor superfamily, member 13B
|
| Other Description |
transmembrane activator and CAML interactor|tumor necrosis factor receptor 13B|tumor necrosis factor receptor superfamily member 13B
|
| Swissprots |
Q32LX4 Q7Z6F5 B7Z6V8 B2R8B0 O14836
|
| Accessions |
ABK41894 BAE16555 CAF03579 CAJ90562 CAJ90567 CAJ90607 CAJ90609 CAM32377 CAZ39523 CBH32710 CBH51785 CBI12200 CBI67647 CBX33267 CBY65601 CBY65603 EAW55728 EAW55729 O14836 AF023614 AAC51790 AK097261 AK223453 BAD97173 AK301032 BAH13394 AK313302 BAG36107 AX766384 CAE00326 AX772740 CAE06248 AY302137 AAP57629 BC109392 AAI09393 NM_012452 NP_036584
|
| Function |
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T- cell function and the regulation of humoral immunity. {ECO:0000269|PubMed:10956646, ECO:0000269|PubMed:10973284}.
|
| Subcellular Location |
Membrane; Single-pass type III membrane protein.
|
| Tissue Specificity |
Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B- cells and activated T-cells, but not in resting T-cells.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Primary immunodeficiency, Intestinal immune network for IgA production
|