| Gene Symbol |
Wtap
|
| Entrez Gene |
60532
|
| Alt Symbol |
2810408K05Rik, 9430038B09Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
Wilms tumour 1-associating protein
|
| Other Description |
WT1-associated protein|Wilms' tumour 1-associating protein|female-lethal(2)D homolog|pre-mRNA-splicing regulator WTAP|wilms tumor 1-associating protein
|
| Swissprots |
Q9ER69 Q566J5 Q3U120
|
| Accessions |
EDL02020 EDL02021 EDL02023 Q9ER69 AJ276707 CAC16790 AK031965 AK041341 AK051702 AK076111 BAC36191 AK156334 BAE33680 AK220249 BAD90174 BC046416 AAH46416 BC047338 BC093504 AAH93504 BU516500 BY016042 XM_006523341 XP_006523404 NM_001113532 NP_001107004 NM_001113533 NP_001107005 NM_175394 NP_780603
|
| Function |
Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000250}. Nucleus speckle {ECO:0000250}.
|