Gene Symbol | Wtap |
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Entrez Gene | 60532 |
Alt Symbol | 2810408K05Rik, 9430038B09Rik |
Species | Mouse |
Gene Type | protein-coding |
Description | Wilms tumour 1-associating protein |
Other Description | WT1-associated protein|Wilms' tumour 1-associating protein|female-lethal(2)D homolog|pre-mRNA-splicing regulator WTAP|wilms tumor 1-associating protein |
Swissprots | Q9ER69 Q566J5 Q3U120 |
Accessions | EDL02020 EDL02021 EDL02023 Q9ER69 AJ276707 CAC16790 AK031965 AK041341 AK051702 AK076111 BAC36191 AK156334 BAE33680 AK220249 BAD90174 BC046416 AAH46416 BC047338 BC093504 AAH93504 BU516500 BY016042 XM_006523341 XP_006523404 NM_001113532 NP_001107004 NM_001113533 NP_001107005 NM_175394 NP_780603 |
Function | Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus, nucleolus {ECO:0000250}. Nucleus speckle {ECO:0000250}. |
WTAP CRISPR/Cas9 KO Plasmid (m) - sc-425635 from Santa Cruz Biotechnology
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WTAP HDR Plasmid (m) - sc-425635-HDR from Santa Cruz Biotechnology
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WTAP Double Nickase Plasmid (m) - sc-425635-NIC from Santa Cruz Biotechnology
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WTAP Double Nickase Plasmid (m2) - sc-425635-NIC-2 from Santa Cruz Biotechnology
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WTAP CRISPR Activation Plasmid (m) - sc-425635-ACT from Santa Cruz Biotechnology
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WTAP CRISPR Activation Plasmid (m2) - sc-425635-ACT-2 from Santa Cruz Biotechnology
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WTAP Lentiviral Activation Particles (m) - sc-425635-LAC from Santa Cruz Biotechnology
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WTAP Lentiviral Activation Particles (m2) - sc-425635-LAC-2 from Santa Cruz Biotechnology
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WTAP siRNA (m) - sc-63225 from Santa Cruz Biotechnology
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WTAP shRNA Plasmid (m) - sc-63225-SH from Santa Cruz Biotechnology
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WTAP shRNA (m) Lentiviral Particles - sc-63225-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN44696 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND44696 from Sigma-Aldrich
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WTAP siRNA (Mouse) - CRM6245 from Cohesion Biosciences
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WTAP - MBS8231086 from MyBioSource
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shRNA set against Mouse Wtap(NM_175394.2) - SHL137064 from Creative biogene
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Mouse WTAP siRNA - orb285721 from Biorbyt
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WTAP shRNA Plasmid (Mouse) - CHM6245 from Cohesion Biosciences
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WTAP miRNA 3'UTR clone - MiUTR1M-12820 from Creative biogene
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