| Gene Symbol |
TXNDC8
|
| Entrez Gene |
255220
|
| Alt Symbol |
SPTRX-3, TRX6, bA427L11.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thioredoxin domain containing 8 (spermatozoa)
|
| Other Description |
sperm-specific thioredoxin 3|spermatid-specific thioredoxin-3|spermatocyte/spermatid-specific thioredoxin-3|thioredoxin 6|thioredoxin domain-containing protein 8
|
| Swissprots |
Q6A555 A6NDK7 Q5T934 A1L4I2
|
| Accessions |
EAW59061 Q6A555 AF305830 AAQ14501 BC035743 BC130549 AAI30550 BC130551 AAI30552 BC144461 AAI44462 HQ258720 ADR83471 HY007335 XM_011518459 XP_011516761 XM_011518460 XP_011516762 XM_011518461 XP_011516763 XM_011518462 XP_011516764 XM_011518463 XP_011516765 XM_011518464 XP_011516766 XR_929743 XR_929744 XR_929745 XR_929746 NM_001003936 NP_001003936 NM_001286946 NP_001273875 NM_001286947 NP_001273876
|
| Function |
May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15181017}. Golgi apparatus {ECO:0000269|PubMed:15181017}.
|
| Tissue Specificity |
Testis-specific. Only expressed during spermiogenesis, prominently in the Golgi apparatus of pachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosome of round spermatids (at protein level). {ECO:0000269|PubMed:15181017}.
|