EIF6

Gene Symbol EIF6
Entrez Gene 3692
Alt Symbol CAB, EIF3A, ITGB4BP, b(2)gcn, eIF-6, p27(BBP), p27BBP
Species Human
Gene Type protein-coding
Description eukaryotic translation initiation factor 6
Other Description B4 integrin interactor|eIF-6|eukaryotic translation initiation factor 3A|p27 beta-4 integrin-binding protein
Swissprots B7ZBG9 P56537 Q96TD5 Q6IBN8
Accessions AAK39426 CAI93602 EAW76219 EAW76220 EAW76221 P56537 AB062289 BAB93472 AF022229 AAB97735 AF047433 AAC39897 AF401207 AK296076 BAG58832 AK314969 BAG37470 AL537456 BC001119 AAH01119 BC011845 AAH11845 BC019305 AAH19305 BC095465 BG283650 BG334381 BM794263 BM851166 BQ222221 CN265282 CR456764 CAG33045 CT002623 DB448068 DQ892592 ABM83518 DQ895811 ABM86737 HG511334 Y11435 CAA72243 NM_001267810 NP_001254739 NM_002212 NP_002203 NM_181466 NP_852131 NM_181468 NP_852133 NR_052022 NR_052023 NR_052024 NM_181467 NM_181469
Function Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity. {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:21536732}.
Subcellular Location Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
Tissue Specificity Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level). {ECO:0000269|PubMed:11290417}.
Top Pathways Ribosome biogenesis in eukaryotes

eIF6 (D16E9) XP ® Rabbit mAb - 3833 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D16E9
Western blot analysis of extracts from various cell types using eIF6 (D16E9) XP ® Rabbit mAb.

eIF6 Antibody - 3263 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using eIF6 Antibody.

eIF6 (FL-245) - sc-366167 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
eIF6 (FL-245): sc-366167. Western blot analysis of eIF6 expression in NIH/3T3 (A), K-562 (B), HeLa (C) and Ramos (D) whole cell lysates.

eIF6 (A-12) - sc-390441 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
eIF6 (A-12): sc-390441. Western blot analysis of eIF6 expression in K-562 (A), RKO (B), Ramos (C), HEK293 (D), MIA PaCa-2 (E) and HeLa (F) whole cell lysates.

eIF6 (A-2) - sc-390432 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
eIF6 (A-2): sc-390432. Western blot analysis of eIF6 expression in K-562 (A), RKO (B), NIH/3T3 (C), HEK293 (D) and MIA PaCa-2 (E) whole cell lysates.

eIF6 (N-14) - sc-70268 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
eIF6 (N-14): sc-70268. Western blot analysis of eIF6 expression in NIH/3T3 whole cell lysate.

eIF6 (V-20) - sc-70270 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
eIF6 (V-20): sc-70270. Western blot analysis of eIF6 expression in non-transfected 293T: sc-117752 (A), mouse eIF6 transfected 293T: sc-126782 (B) and NIH/3T3 (C) whole cell lysates.

Anti-Integrin beta 4 binding protein antibody - ab191017 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin-embedded human placenta tissue labeling Integrin beta 4 binding protein with ab191017 at 1 µg/ml.

Anti-Integrin beta 4 binding protein antibody [EPR6512(B)] - ab124839 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6512(B)
All lanes : Anti-Integrin beta 4 binding protein antibody [EPR6512(B)] (ab124839) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : RAW 264.7 cell lysateLane 3 : K562 cell lysateLane 4 : 293T cell lysateLane 5 : HepG2 cell lysateLysates/proteins at 10 µg per lane.

Anti-Integrin beta 4 binding protein antibody [EPR6513] - ab133321 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6513
All lanes : Anti-Integrin beta 4 binding protein antibody [EPR6513] (ab133321) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : 293T cell lysateLane 3 : HepG2 cell lysateLane 4 : K562 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-EIF6 Antibody (aa82-96) - LS-C313157 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
EIF6 antibody. IHC(F): Human Placenta Tissue.

Anti-EIF6 Antibody (aa145-194) - LS-C145559 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
EIF6 / ITGB4BP antibody LS-C145559 Western blot of Fetal Liver lysate. Antibody concentration 1 ug/ml.

Anti-EIF6 Antibody (N-Terminus) - LS-C145397 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
EIF6 / ITGB4BP antibody LS-C145397 Western blot of HeLa Cell lysate. Antibody concentration 1 ug/ml.

Anti-EIF6 Antibody (aa150-200) - LS-C289734 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EIF6 Antibody (aa50-100) - LS-C289735 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EIF6 Antibody (C-Terminus, clone EPR6513) - LS-C152335 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6513
Western blot analysis on (A) HeLa, (B) 293T, (C) HepG2, and (D) K562 cell lysates using anti-ITGB4BP antibody.

Anti-EIF6 Antibody (Internal, clone EPR6512(B)) - LS-C138943 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6512(B)
IHC of paraffin-embedded human colonic adenocarcinoma using anti-eIF-6 antibody.

Anti-EIF6 Antibody - LS-C192810 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of COLO 320 cell lines, using EIF6 antibody.

Anti-EIF6 Antibody - LS-C331705 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of MCF7 cell using EIF6 antibody. Blue: DAPI for nuclear staining.

integrin beta 4 binding protein Antibody - NBP2-13954 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: integrin beta 4 binding protein Antibody [NBP2-13954] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

integrin beta 4 binding protein Antibody - NBP1-52641 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

integrin beta 4 binding protein Antibody - NBP1-52640 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: integrin beta 4 binding protein Antibody [NBP1-52640] - Affinity purified rabbit anti-eIF6 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 6 mcg/mg lysate. eIF6 was also immunoprecipitated by rabbit anti-eIF6 antibody NBP1-52641, which recognizes a downstream epitope.

integrin beta 4 binding protein Antibody - NBP2-16975 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

integrin beta 4 binding protein Antibody - H00003692-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: integrin beta 4 binding protein Antibody [H00003692-A01] - ITGB4BP polyclonal antibody (A01), Lot # 051122JC01 Western Blot analysis of ITGB4BP expression in HL-60 ( Cat # L014V1 ).

Anti-EIF6 antibody produced in rabbit - HPA040873 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-EIF6:<B>Cat. No. HPA040873</B>: Immunohistochemical staining of human testis shows strong cytoplasmic and nuclear positivity in cells in seminiferus ducts.
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