EIF6

Gene Symbol	EIF6
Entrez Gene	3692
Alt Symbol	CAB, EIF3A, ITGB4BP, b(2)gcn, eIF-6, p27(BBP), p27BBP
Species	Human
Gene Type	protein-coding
Description	eukaryotic translation initiation factor 6
Other Description	B4 integrin interactor|eIF-6|eukaryotic translation initiation factor 3A|p27 beta-4 integrin-binding protein
Swissprots	B7ZBG9 P56537 Q96TD5 Q6IBN8
Accessions	AAK39426 CAI93602 EAW76219 EAW76220 EAW76221 P56537 AB062289 BAB93472 AF022229 AAB97735 AF047433 AAC39897 AF401207 AK296076 BAG58832 AK314969 BAG37470 AL537456 BC001119 AAH01119 BC011845 AAH11845 BC019305 AAH19305 BC095465 BG283650 BG334381 BM794263 BM851166 BQ222221 CN265282 CR456764 CAG33045 CT002623 DB448068 DQ892592 ABM83518 DQ895811 ABM86737 HG511334 Y11435 CAA72243 NM_001267810 NP_001254739 NM_002212 NP_002203 NM_181466 NP_852131 NM_181468 NP_852133 NR_052022 NR_052023 NR_052024 NM_181467 NM_181469
Function	Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity. {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:21536732}.
Subcellular Location	Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
Tissue Specificity	Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level). {ECO:0000269|PubMed:11290417}.
Top Pathways	Ribosome biogenesis in eukaryotes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Integrin beta 4 binding protein full length protein - ab132440 from Abcam Category Protein Source Wheat germ Species Human

Human Integrin beta 4 binding protein peptide - ab90213 from Abcam Category Peptide

Human Integrin beta 4 binding protein protein fragment - ab116841 from Abcam Category Protein Source Wheat germ Species Human

EIF3A Antibody Blocking Peptide - LS-E2067 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EIF3A Antibody Blocking Peptide - LS-E22528 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EIF6 Antibody Blocking Peptide - LS-E25168 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EIF6 Antibody Blocking Peptide - LS-E22446 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human EIF3A Protein - H00008661-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human integrin beta 4 binding protein Protein - H00003692-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human integrin beta 4 binding protein Protein - H00003692-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EIF6 Blocking Peptide - 33R-10387 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EIF6 Blocking Peptide - 33R-1613 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EIF6 / ITGB4BP - H00003692-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EIF6 / ITGB4BP - H00003692-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EIF6 / ITGB4BP - H00003692-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EIF6 / ITGB4BP - H00003692-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EIF3A fusion protein - Ag22515 from Proteintech Group Category Protein Species Human

EIF6 fusion protein - Ag0324 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Eukaryotic Translation Initiation Factor 6, T7-tagged - EIF6-2911H from Creative Biomart Category Protein

Recombinant Human EIF6 - EIF6-26861TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human EIF6, GST-tagged - EIF6-12391H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Eukaryotic Translation Initiation Factor 6 (EIF6) - RPL487Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Eukaryotic Translation Initiation Factor 6 (EIF6) - RPL487Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Eukaryotic translation initiation factor 6 - CSB-YP007582TQY CSB-EP007582TQY CSB-BP007582TQY CSB-MP007582TQY from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Trypanosoma

Recombinant Human Eukaryotic translation initiation factor 6(EIF6) - CSB-YP007582HU CSB-EP007582HU CSB-BP007582HU CSB-MP007582HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Search more