| Gene Symbol | EIF6 |
|---|---|
| Entrez Gene | 3692 |
| Alt Symbol | CAB, EIF3A, ITGB4BP, b(2)gcn, eIF-6, p27(BBP), p27BBP |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 6 |
| Other Description | B4 integrin interactor|eIF-6|eukaryotic translation initiation factor 3A|p27 beta-4 integrin-binding protein |
| Swissprots | B7ZBG9 P56537 Q96TD5 Q6IBN8 |
| Accessions | AAK39426 CAI93602 EAW76219 EAW76220 EAW76221 P56537 AB062289 BAB93472 AF022229 AAB97735 AF047433 AAC39897 AF401207 AK296076 BAG58832 AK314969 BAG37470 AL537456 BC001119 AAH01119 BC011845 AAH11845 BC019305 AAH19305 BC095465 BG283650 BG334381 BM794263 BM851166 BQ222221 CN265282 CR456764 CAG33045 CT002623 DB448068 DQ892592 ABM83518 DQ895811 ABM86737 HG511334 Y11435 CAA72243 NM_001267810 NP_001254739 NM_002212 NP_002203 NM_181466 NP_852131 NM_181468 NP_852133 NR_052022 NR_052023 NR_052024 NM_181467 NM_181469 |
| Function | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity. {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:21536732}. |
| Subcellular Location | Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus. |
| Tissue Specificity | Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level). {ECO:0000269|PubMed:11290417}. |
| Top Pathways | Ribosome biogenesis in eukaryotes |
Human EIF6 ELISA Kit (Sandwich ELISA) - LS-F7637 from LifeSpan Bioscience
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Human eIF3a ELISA Kit - abx054739 from Abbexa
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Human EIF6 ELISA Kit - abx151390 from Abbexa
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Eukaryotic Translation Initiation Factor 3a, eIF3a, Human, ELISA Kit - E-EL-H2283 from ARP American Research Products
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Eukaryotic translation initiation factor 3 subunit A, EIF3A, Human, ELISA Kit - E1885h from ARP American Research Products
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Eukaryotic Translation Initiation Factor 3A, Human, ELISA Kit - E01E0047 from ARP American Research Products
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Eukaryotic Translation Initiation Factor 6 (EIF6), Human, ELISA Kit - SEL487Hu from ARP American Research Products
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Eukaryotic Translation Initiation Factor 3A, EIF3A, Mouse, ELISA Kit - E-EL-M0478 from ARP American Research Products
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Eukaryotic Translation Initiation Factor 3a, eIF3a, Rabbit, ELISA Kit - E-EL-RB0175 from ARP American Research Products
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Eukaryotic Translation Initiation Factor 3a, eIF3a, Chicken, ELISA Kit - E-EL-Ch1940 from ARP American Research Products
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Eukaryotic Translation Initiation Factor 3a, eIF3a, Porcine, ELISA Kit - E-EL-P1820 from ARP American Research Products
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Eukaryotic Translation Initiation Factor 3a, eIF3a, Sheep, ELISA Kit - E-EL-S0440 from ARP American Research Products
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Eukaryotic Translation Initiation Factor 3a, eIF3a, Monkey, ELISA Kit - E-EL-MK1879 from ARP American Research Products
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Human EIF3A ELISA Kit - HE0054 from NeoScientific
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Anserine EIF3A ELISA Kit - AE0054 from NeoScientific
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Human eIF3a(Eukaryotic Translation Initiation Factor 3a) ELISA Kit - E-EL-H2283 from Elabscience
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Eukaryotic Translation Initiation Factor 6, ELISA Kit - MBS073483 from MyBioSource
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Eukaryotic Translation Initiation Factor 6, ELISA Kit - MBS050504 from MyBioSource
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Eukaryotic Translation Initiation Factor 6, ELISA Kit - MBS063368 from MyBioSource
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Eukaryotic Translation Initiation Factor 6, ELISA Kit - MBS108686 from MyBioSource
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Eukaryotic Translation Initiation Factor 6, ELISA Kit - MBS059320 from MyBioSource
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Eukaryotic Translation Initiation Factor 6, ELISA Kit - MBS080875 from MyBioSource
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Eukaryotic Translation Initiation Factor 6, ELISA Kit - MBS048888 from MyBioSource
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integrin beta 4 binding protein (ITGB4BP) , ELISA Kit - MBS9310872 from MyBioSource
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ELISA Kit for Eukaryotic Translation Initiation Factor 6 (EIF6) - SEL487Hu from Uscn Life Science Inc.
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