| Gene Symbol | EIF6 |
|---|---|
| Entrez Gene | 3692 |
| Alt Symbol | CAB, EIF3A, ITGB4BP, b(2)gcn, eIF-6, p27(BBP), p27BBP |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 6 |
| Other Description | B4 integrin interactor|eIF-6|eukaryotic translation initiation factor 3A|p27 beta-4 integrin-binding protein |
| Swissprots | B7ZBG9 P56537 Q96TD5 Q6IBN8 |
| Accessions | AAK39426 CAI93602 EAW76219 EAW76220 EAW76221 P56537 AB062289 BAB93472 AF022229 AAB97735 AF047433 AAC39897 AF401207 AK296076 BAG58832 AK314969 BAG37470 AL537456 BC001119 AAH01119 BC011845 AAH11845 BC019305 AAH19305 BC095465 BG283650 BG334381 BM794263 BM851166 BQ222221 CN265282 CR456764 CAG33045 CT002623 DB448068 DQ892592 ABM83518 DQ895811 ABM86737 HG511334 Y11435 CAA72243 NM_001267810 NP_001254739 NM_002212 NP_002203 NM_181466 NP_852131 NM_181468 NP_852133 NR_052022 NR_052023 NR_052024 NM_181467 NM_181469 |
| Function | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity. {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:21536732}. |
| Subcellular Location | Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus. |
| Tissue Specificity | Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level). {ECO:0000269|PubMed:11290417}. |
| Top Pathways | Ribosome biogenesis in eukaryotes |