ECT2

Gene Symbol	ECT2
Entrez Gene	1894
Alt Symbol	ARHGEF31
Species	Human
Gene Type	protein-coding
Description	epithelial cell transforming 2
Other Description	epithelial cell transforming sequence 2 oncogene|epithelial cell-transforming sequence 2 oncogene|protein ECT2
Swissprots	Q6U836 Q9H8V3 Q9NVW9 Q2M269 Q0MT80 Q9NSV8
Accessions	CAM84950 CCA61729 CCA64133 CCA64578 CCA64581 CCB07385 CCQ77688 CCQ77697 CCQ77706 CCQ77715 CDH48194 CDH61616 CDH61670 CDH61689 CDH88987 CDH92525 CDH92539 CDH92550 CDH92797 CDH92894 CDI44669 CDI44678 EAW78460 EAW78461 Q9H8V3 AK001323 BAA91624 AK001515 AK023267 BAB14498 AK027713 BAB55317 AK308391 AK314581 BAG37157 AL137710 CAB70886 AY376439 AAQ83675 BC006838 AAH06838 BC006987 BC070038 BC112086 AAI12087 DB229273 DC406772 DQ847274 ABH10140 XM_005247176 XP_005247233 XM_006713523 XP_006713586 XM_006713524 XP_006713587 XM_011512514 XP_011510816 XM_011512515 XP_011510817 XM_011512516 XP_011510818 NM_001258315 NP_001245244 NM_001258316 NP_001245245 NM_018098 NP_060568
Function	Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth
Subcellular Location	Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cell junction. Cell junction, tight junction. Note=Sequestered within the nucleus during interphase. Dispersed throughout the cytoplasm upon breakdown of the nuclear envelope during mitosis. Colocalizes with the centralspindlin complex to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalized with RhoA at the midbody. Its subcellular localization to tight junction is increased by calcium. Localized predominantly in the cytoplasm of numerous carcinoma cells.
Tissue Specificity	Expressed in lung epithelial cells (at protein level). Expressed in squamous cell carcinoma, primary non-small cell lung cancer tumors and lung adenocarcinoma. {ECO:0000269|PubMed:19617897}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ECT2 peptide - ab23060 from Abcam Category Peptide Species Human

ECT2 Antibody Blocking Peptide - LS-E3558 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ECT2 Antibody Blocking Peptide - LS-E25556 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ECT2 Antibody Blocking Peptide - LS-E18834 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ECT2-Antibody-Center-Blocking-Peptide - BP14755c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ECT2 blocking peptide - GTX24863-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

ECT2 Blocking Peptide - 33R-7035 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ECT2 Blocking Peptide - 33R-4471 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human ECT2 Protein - abx066450 from Abbexa Category Protein Source E.coli Species Human

Human ECT2 Protein - abx066451 from Abbexa Category Protein Source E.coli Species Human

ECT2 Peptide - AC21-0385-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ECT2 - H00001894-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ECT2 - H00001894-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Epithelial Cell Transforming Sequence 2 (ECT2), Human - 20-8483 from ARP American Research Products Category Protein Prices $519.00 Sizes 50 µg Source E.coli Species Human

Epithelial Cell Transforming Sequence 2 (ECT2), Human - 20-8484 from ARP American Research Products Category Protein Prices $519.00 Sizes 50 µg Source E.coli Species Human

ECT2 Peptide - 45-517P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Epithelial Cell Transforming Sequence 2 (ECT2) - RPC451Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Epithelial Cell Transforming Sequence 2 (ECT2) - RPC451Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Human Protein ECT2(ECT2) ,partial - CSB-YP888001HU CSB-EP888001HU CSB-BP888001HU CSB-MP888001HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ECT2, Peptide - MBS425684 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

ECT2 fusion protein - Ag24836 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

ECT2 Peptide, Human - M34GP04703H from Creative Peptides Category Peptide Source Synthetic. Species Human

ECT2 Immunizing peptide - orb17767 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg

ECT2 Recombinant Protein (OPCD02842) - OPCD02842 from Aviva Systems Biology Category Protein Source E.coli Species Human

ECT2 Recombinant Protein (OPCD02843) - OPCD02843 from Aviva Systems Biology Category Protein Source E.coli Species Human

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