ECT2

Gene Symbol ECT2
Entrez Gene 1894
Alt Symbol ARHGEF31
Species Human
Gene Type protein-coding
Description epithelial cell transforming 2
Other Description epithelial cell transforming sequence 2 oncogene|epithelial cell-transforming sequence 2 oncogene|protein ECT2
Swissprots Q6U836 Q9H8V3 Q9NVW9 Q2M269 Q0MT80 Q9NSV8
Accessions CAM84950 CCA61729 CCA64133 CCA64578 CCA64581 CCB07385 CCQ77688 CCQ77697 CCQ77706 CCQ77715 CDH48194 CDH61616 CDH61670 CDH61689 CDH88987 CDH92525 CDH92539 CDH92550 CDH92797 CDH92894 CDI44669 CDI44678 EAW78460 EAW78461 Q9H8V3 AK001323 BAA91624 AK001515 AK023267 BAB14498 AK027713 BAB55317 AK308391 AK314581 BAG37157 AL137710 CAB70886 AY376439 AAQ83675 BC006838 AAH06838 BC006987 BC070038 BC112086 AAI12087 DB229273 DC406772 DQ847274 ABH10140 XM_005247176 XP_005247233 XM_006713523 XP_006713586 XM_006713524 XP_006713587 XM_011512514 XP_011510816 XM_011512515 XP_011510817 XM_011512516 XP_011510818 NM_001258315 NP_001245244 NM_001258316 NP_001245245 NM_018098 NP_060568
Function Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth
Subcellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cell junction. Cell junction, tight junction. Note=Sequestered within the nucleus during interphase. Dispersed throughout the cytoplasm upon breakdown of the nuclear envelope during mitosis. Colocalizes with the centralspindlin complex to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalized with RhoA at the midbody. Its subcellular localization to tight junction is increased by calcium. Localized predominantly in the cytoplasm of numerous carcinoma cells.
Tissue Specificity Expressed in lung epithelial cells (at protein level). Expressed in squamous cell carcinoma, primary non-small cell lung cancer tumors and lung adenocarcinoma. {ECO:0000269|PubMed:19617897}.

Ect2 CRISPR/Cas9 KO Plasmid (h) - sc-401538 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ect2 HDR Plasmid (h) - sc-401538-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ect2 Double Nickase Plasmid (h) - sc-401538-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ect2 Double Nickase Plasmid (h2) - sc-401538-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ect2 CRISPR Activation Plasmid (h) - sc-401538-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ect2 CRISPR Activation Plasmid (h2) - sc-401538-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ect2 Lentiviral Activation Particles (h) - sc-401538-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ect2 Lentiviral Activation Particles (h2) - sc-401538-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ect2 siRNA (h) - sc-35259 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ect2 shRNA Plasmid (h) - sc-35259-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ect2 shRNA (h) Lentiviral Particles - sc-35259-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU037471 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7641 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7641 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ECT2 siRNA (Human) - CRH1320 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ECT2 - MBS8229414 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ECT2 (NM_018098.5) - SHH283021 from Creative biogene

Category siRNA
Species Reactivities Human

Human ECT2 siRNA - orb261822 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ECT2 shRNA Plasmid (Human) - CHH1320 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ECT2 miRNA 3'UTR clone - MiUTR3H-03499 from Creative biogene

Species Reactivities Human
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