| Gene Symbol |
BCO1
|
| Entrez Gene |
53630
|
| Alt Symbol |
BCDO, BCDO1, BCMO, BCMO1, BCO
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
beta-carotene oxygenase 1
|
| Other Description |
beta,beta-carotene 15,15'-monooxygenase|beta-carotene 15, 15'-dioxygenase 1|beta-carotene 15,15'-monooxygenase 1|beta-carotene dioxygenase 1
|
| Swissprots |
A0AV48 Q9HAY6 Q9NVH5 A0AV50
|
| Accessions |
EAW95537 EAW95538 Q9HAY6 AF294900 AAG15380 AK001592 BAA91776 AK296011 BAG58782 BC022269 BC126210 AAI26211 BC126212 AAI26213 HQ258298 ADR83052 XM_011523109 XP_011521411 XM_011523110 XP_011521412 NM_017429 NP_059125
|
| Function |
Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.
|
| Tissue Specificity |
Highly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon. {ECO:0000269|PubMed:11401432}.
|
| Top Pathways |
Retinol metabolism
|