| Gene Symbol |
Gabarapl2
|
| Entrez Gene |
93739
|
| Alt Symbol |
0610012F20Rik, 2900019O08Rik, AI173605, GATE-16, Gef2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2
|
| Other Description |
GABA(A) receptor-associated protein like 2|GABA(A) receptor-associated protein-like 2|gamma-aminobutyric acid (GABA-A) receptor-associated protein-like 2|gamma-aminobutyric acid receptor-associated protein-like 2|ganglioside expression factor 2|golgi-associated ATPase enhancer of 16 kDa
|
| Swissprots |
P60521
|
| Accessions |
EDL11519 P60521 AF190644 AAK16238 AI845404 AK002596 BAB22217 AK013563 AK049819 BAC33933 AK134873 AK184306 BC026798 AAH26798 BC081436 AAH81436 NM_026693 NP_080969
|
| Function |
Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000250}.
|
| Subcellular Location |
Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. A high level expression is seen in brain, thymus, lung, heart, liver and kidney. {ECO:0000269|PubMed:11414770}.
|
| Top Pathways |
GABAergic synapse, Regulation of autophagy
|