Gene Symbol | BPNT1 |
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Entrez Gene | 10380 |
Alt Symbol | HEL20, PIP |
Species | Human |
Gene Type | protein-coding |
Description | 3'(2'), 5'-bisphosphate nucleotidase 1 |
Other Description | 3'(2'),5'-bisphosphate nucleotidase 1|BPntase|PAP-inositol 1,4-phosphatase|PAP-inositol-1,4-phosphatase|bisphosphate 3'-nucleotidase 1|epididymis luminal protein 20 |
Swissprots | Q9UGJ3 A8K7C8 O95861 Q8WVL5 B4DUS9 D3DTA9 B4DPS5 |
Accessions | EAW93306 EAW93307 EAW93308 O95861 AF125042 AAD17329 AJ249339 CAB65115 AK021941 AK291943 BAF84632 AK298476 BAG60687 AK300777 BAG62441 AK315962 BAH14333 BC017801 AAH17801 BG114910 BG428446 DC368603 EU794594 ACJ13648 XM_005272998 XP_005273055 XM_005272999 XP_005273056 XM_005273000 XP_005273057 XM_005273004 XP_005273061 XM_005273005 XP_005273062 XM_006711114 XP_006711177 XM_011509063 XP_011507365 XM_011509064 XP_011507366 XM_011509065 XP_011507367 NM_001286149 NP_001273078 NM_001286150 NP_001273079 NM_001286151 NP_001273080 NM_006085 NP_006076 |
Function | Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6. {ECO:0000269|PubMed:10224133}. |
Tissue Specificity | Highly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain, placenta, lung and skeletal muscle. {ECO:0000269|PubMed:10224133}. |
Top Pathways | Sulfur metabolism |
BPNT1 CRISPR/Cas9 KO Plasmid (h) - sc-408183 from Santa Cruz Biotechnology
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BPNT1 HDR Plasmid (h) - sc-408183-HDR from Santa Cruz Biotechnology
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BPNT1 Double Nickase Plasmid (h) - sc-408183-NIC from Santa Cruz Biotechnology
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BPNT1 Double Nickase Plasmid (h2) - sc-408183-NIC-2 from Santa Cruz Biotechnology
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BPNT1 CRISPR Activation Plasmid (h) - sc-408183-ACT from Santa Cruz Biotechnology
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BPNT1 CRISPR Activation Plasmid (h2) - sc-408183-ACT-2 from Santa Cruz Biotechnology
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BPNT1 Lentiviral Activation Particles (h) - sc-408183-LAC from Santa Cruz Biotechnology
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BPNT1 Lentiviral Activation Particles (h2) - sc-408183-LAC-2 from Santa Cruz Biotechnology
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BPNT1 siRNA (h) - sc-88049 from Santa Cruz Biotechnology
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BPNT1 shRNA Plasmid (h) - sc-88049-SH from Santa Cruz Biotechnology
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BPNT1 shRNA (h) Lentiviral Particles - sc-88049-V from Santa Cruz Biotechnology
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BPNT1 RNAi - H00010380-R02 from Novus Biologicals
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MISSION® esiRNA - EHU064761 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0045 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0043 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0044 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4040 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4040 from Sigma-Aldrich
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BPNT1 siRNA (Human) - CRH7031 from Cohesion Biosciences
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BPNT1 - MBS8205977 from MyBioSource
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shRNA set against Human BPNT1 (NM_006085.4) - SHH247494 from Creative biogene
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shRNA set against Human BPNT1(NM_006085.4) - SHG103591 from Creative biogene
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BPNT1 shRNA Plasmid (Human) - CHH7031 from Cohesion Biosciences
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BPNT1 miRNA 3'UTR clone - MiUTR1H-00934 from Creative biogene
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