| Gene Symbol |
RIC1
|
| Entrez Gene |
57589
|
| Alt Symbol |
CIP150, KIAA1432, bA207C16.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB6A GEF complex partner 1
|
| Other Description |
RAB6A-GEF complex partner protein 1|connexin 43-interacting protein 150 kDa|connexin-43-interacting protein of 150 kDa|protein RIC1 homolog
|
| Swissprots |
B7ZM67 Q4VXJ9 G5E932 B2RN24 Q4VXJ8 Q9H0A5 Q76MT5 Q8TEH4 Q4ADV7 Q9H9S1 Q8N6E0
|
| Accessions |
EAW58759 EAW58760 EAW58761 Q4ADV7 AA250979 AB037853 BAA92670 AB205401 BAE16982 AK022642 BAB14150 AK074150 BAB84976 AK124394 AL136875 CAB66809 BC023535 BC030576 AAH30576 BC041044 BC136616 AAI36617 BC144296 AAI44297 R44399 XM_005251523 XP_005251580 XM_011517967 XP_011516269 XM_011517968 XP_011516270 XR_428426 NM_001135920 NP_001129392 NM_001206557 NP_001193486 NM_020829 NP_065880
|
| Function |
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. {ECO:0000269|PubMed:16112082, ECO:0000269|PubMed:23091056}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:23091056}. Membrane {ECO:0000269|PubMed:23091056}; Single-pass membrane protein {ECO:0000255}.
|
| Tissue Specificity |
Present in kidney and various cell lines (at protein level). Widely expressed at low level. {ECO:0000269|PubMed:10718198, ECO:0000269|PubMed:16112082}.
|