Gene Symbol | IKZF3 |
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Entrez Gene | 22806 |
Alt Symbol | AIO, AIOLOS, ZNFN1A3 |
Species | Human |
Gene Type | protein-coding |
Description | IKAROS family zinc finger 3 (Aiolos) |
Other Description | zinc finger DNA binding protein Aiolos|zinc finger protein Aiolos|zinc finger protein, subfamily 1A, 3 (Aiolos) |
Swissprots | Q69BM1 Q8WWR1 Q8WWQ9 Q69BM5 B4DVV5 Q69BL8 Q69BL7 Q69BL6 Q69BL9 Q69BM0 Q8N574 Q8WWR0 Q69BM2 Q9UKT9 Q8WWR2 Q69BM3 Q8WWR3 |
Accessions | EAW60604 EAW60605 EAW60606 EAW60607 EAW60608 EAW60609 Q9UKT9 AF086054 AF129512 AAF13493 AI866838 AJ292565 CAC80427 AJ292566 CAC80428 AJ292567 CAC80429 AJ292568 CAC80430 AJ292569 CAC80431 AK128436 AK301250 BAG62817 AK303495 BAG64529 AY377973 AAR84584 AY377975 AAR84586 AY377976 AAR84587 AY377977 AAR84588 AY377978 AAR84589 AY377979 AAR84590 AY377980 AAR84591 AY377981 AAR84592 AY377982 AAR84593 BC032707 AAH32707 EU446776 ABZ92305 HG509027 JF432186 ADZ15403 NM_001257408 NP_001244337 NM_001257409 NP_001244338 NM_001257410 NP_001244339 NM_001257411 NP_001244340 NM_001257412 NP_001244341 NM_001257413 NP_001244342 NM_001257414 NP_001244343 NM_001284514 NP_001271443 NM_001284515 NP_001271444 NM_001284516 NP_001271445 NM_012481 NP_036613 NM_183228 NP_899051 NM_183229 NP_899052 NM_183230 NP_899053 NM_183231 NP_899054 NM_183232 NP_899055 |
Function | Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner. {ECO:0000269|PubMed:10369681}. |
Subcellular Location | Nucleus. Cytoplasm. |
Tissue Specificity | Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus. {ECO:0000269|PubMed:17646674}. |
Human IKZF3 full length protein - ab132618 from Abcam
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Human IKZF3 peptide - ab88208 from Abcam
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Human IKZF3 peptide - ab88209 from Abcam
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IKZF3 peptide - ab184024 from Abcam
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IKZF3 / AIOLOS Antibody Blocking Peptide - LS-E7920 from LifeSpan Bioscience
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IKZF3 / AIOLOS Antibody Blocking Peptide - LS-E14063 from LifeSpan Bioscience
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Recombinant Human Aiolos/IKZF3 Protein - H00022806-P01 from Novus Biologicals
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IKZF3-Antibody-Center-Blocking-peptide - BP5656c from Abgent, a WuXi AppTec company
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IKZF3 Blocking Peptide - 33R-4872 from Fitzgerald
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IKZF3 Blocking Peptide - 33R-4666 from Fitzgerald
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ZNFN1A3 (IKZF3, Aiolos) - H00022806-P01-10 from Acris Antibodies
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ZNFN1A3 (IKZF3, Aiolos) - H00022806-P01-25 from Acris Antibodies
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IKZF3 fusion protein - Ag5537 from Proteintech Group
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IKZF3 fusion protein - ag4434 from Proteintech Group
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Recombinant Human IKZF3, His-tagged - IKZF3-14138H from Creative Biomart
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AIOLOS Blocking Peptide - CBP4020 from Cohesion Biosciences
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Recombinant Human Zinc finger protein Aiolos(IKZF3) - CSB-YP892336HU CSB-EP892336HU CSB-BP892336HU CSB-MP892336HU from Cusabio
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ZNFN1A3 (IKZF3, Aiolos) (transcript variant 1) - TP307547 from Acris Antibodies
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ZNFN1A3 (IKZF3, Aiolos) (transcript variant 5) - TP319750 from Acris Antibodies
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Zinc finger protein Aiolos (IKZF3) , Recombinant Protein - MBS1399766 from MyBioSource
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AIOLOS Blocking Peptide - abx162513 from Abbexa
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Aiolos/IKZF3 Recombinant Protein Antigen - NBP1-89185PEP from Novus Biologicals
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IKZF3 Peptide, Human - M34GP07525H from Creative Peptides
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