STAT2

Gene Symbol STAT2
Entrez Gene 6773
Alt Symbol ISGF-3, P113, STAT113
Species Human
Gene Type protein-coding
Description signal transducer and activator of transcription 2, 113kDa
Other Description interferon alpha induced transcriptional activator|signal transducer and activator of transcription 2|signal transducer and activator of transcription 2, 113kD
Swissprots Q16431 G3V2M6 Q16430 B4DLC7 P52630 Q9UDL4
Accessions AAA98760 AAB36225 AAB36226 AAB36227 AAS00091 AFM91190 AFM91191 AFM91192 AFM91193 AFM91194 AFM91195 AFM91196 AFM91197 AFM91198 AFM91199 AFM91200 AFM91201 AFM91202 AFM91203 AFM91204 AFM91205 AFM91206 AFM91207 AFM91208 AFM91209 AFM91210 AFM91211 AFM91212 AFM91213 AFM91214 AFM91215 AFM91216 AFM91217 AFM91218 AFM91219 AFM91220 AFM91221 AFM91222 AFM91223 AFM91224 AFM91225 AFM91226 AFM91227 AFM91228 AFM91229 AFM91230 AFM91231 AFM91232 AFM91233 AFM91234 AFM91235 AFM91236 AFM91237 AFM91238 AFM91239 AFM91240 AFM91241 AFM91242 AFM91243 AFM91244 AFM91245 AFM91246 AFM91247 AFM91248 AFM91249 AFM91250 AFM91251 AFM91252 AFM91253 AFM91254 AFM91255 AFM91256 AFM91257 AFM91258 AFM91259 AFM91260 AFM91261 AFM91262 AFM91263 AFM91264 AFM91265 AFM91266 AFM91267 AFM91268 AFM91269 AFM91270 AFM91271 AFM91272 AFM91273 AFM91274 AFM91275 AFM91276 AFM91277 AFM91278 AFM91279 AFM91280 CAM91176 EAW96934 EAW96935 EAW96936 EAW96937 P52630 AK094039 AK295052 BAG58101 AK295114 BAG58143 AK296939 BAG59489 AK296940 BAG59490 AK308051 AK310727 AK316516 BAH14887 BC006092 AAH06092 BC051284 AAH51284 BX640607 CAE45713 CD684210 DB482283 M97934 XM_005269110 XP_005269167 XM_005269111 XP_005269168 XM_011538697 XP_011536999 XM_011538698 XP_011537000 XM_011538699 XP_011537001 XM_011538700 XP_011537002 XM_011538701 XP_011537003 XM_011538702 XP_011537004 XR_245953 XR_245954 NM_005419 NP_005410 NM_198332 NP_938146
Function Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. {ECO:0000269|PubMed:9020188}.
Subcellular Location Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
Top Pathways Jak-STAT signaling pathway, Chemokine signaling pathway, Hepatitis C, Osteoclast differentiation, Measles

Phospho-Stat2 (Tyr690) Antibody - 4441 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated or IFN-α-treated (100 ng/ml, 15 minutes), using Stat2 Antibody (upper) or Phospho-Stat2 (Tyr690) Antibody (lower).

Stat2 Antibody - 4594 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from K562 and SW620 cells, using Stat2 Antibody.

Stat2 (A-7) - sc-1668 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Stat2 p113 expression in Ramos cells (A,B). Antibodies tested include Stat2 (A-7): sc-1668 (A) and Stat2 (C-20): sc-476 (B).

Stat2 (A-9) - sc-166201 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Stat2 (A-9): sc-166201. Western blot analysis of Stat2 expression in ZR-75-1 (A) and Ramos (B) whole cell lysates.

Stat2 (C-20) - sc-476 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Stat2 (C-20): sc-476. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing cytoplasmic and nuclear staining.

Stat2 (B-3) - sc-514193 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Stat2 (B-3): sc-514193. Western blot analysis of Stat2 expression in Ramos whole cell lysate.

Stat2 (H-190) - sc-22816 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Stat2 (H-190): sc-22816. Western blot analysis of Stat2 expression in ZR-75-1 whole cell lysate.

Stat2 (L-20) - sc-950 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Stat2 (L-20): sc-950. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urinary bladder tissue showing cytoplasmic and nuclear staining of urothelial cells.

Stat2 (N-17) - sc-839 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Stat2 (N-17): sc-839. Immunofluorescence staining of methanol-fixed Ramos cells showing nuclear localization.

Stat2 (22) - sc-136079 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Stat2 (22): sc-136079. Western blot analysis of Stat2 expression in K-562 whole cell lysate.

p-Stat2 (Tyr 690)-R - sc-21689-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
p-Stat2 (Tyr 690)-R: sc-21689-R. Western blot analysis of Stat2 phosphorylation in untreated (A) and lambda protein phosphatase treated (B) HeLa whole cell lysates.

Anti-STAT2 (phospho Y631) antibody - ab111609 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111609 at 1/50 dilution staining STAT2 in paraffin-embedded Human Colon carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-STAT2 (phospho Y690) antibody - ab53132 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-STAT2 (phospho Y690) antibody (ab53132) at 1/300 dilutionLane 1 : HeLa cell extract treated with IFN (2500U/ml, 30mins)Lane 2 : HeLa cell extract treated with IFN (2500U/ml, 30mins) with immunising peptide

Anti-STAT2 (phospho Y690) antibody - ab195849 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-STAT2 (phospho Y690) antibody (ab195849) at 1/500 dilutionLane 1 : IFN treated HeLa whole cell lysates with antigen-specific peptideLane 2 : IFN treated HeLa whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-STAT2 antibody - ab93445 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab93445 stained PC12 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab93445 at 10µg/ml overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti- rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-STAT2 antibody - ab53149 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of STAT2 in paraffin embedded human lung carcinoma tissue using ab53149 at a dilution of 1/50. Right hand image: treated with immunising peptide. Left hand image: untreated.

Anti-STAT2 antibody - ab7965 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-STAT2 antibody - ab10624 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-STAT2 antibody - ab58014 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-STAT2 antibody - ab124283 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of STAT2 by Western Blot of Immunprecipitate. anti-STAT2 antibody at 1µg/ml staining STAT2 in Jurkat whole cell lysate immunoprecipitated using ab123283 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 3 seconds.

Anti-STAT2 antibody [19G8.H2.H6] - ab106094 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 19G8.H2.H6
Anti-STAT2 antibody [19G8.H2.H6] (ab106094) at 1/1000 dilution + HeLa whole cell lysate at 1 µg

Anti-STAT2 antibody [MM0919-27L19] - ab201568 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0919-27L19

Anti-STAT2 antibody [Y141] - ab32367 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y141
Anti-STAT2 antibody [Y141] (ab32367) at 1/500 dilution + K562 cell lysate

Anti-STAT2 Antibody (C-Terminus) - LS-C51704 from LifeSpan Bioscience

Prices $295.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-STAT2 Antibody (phospho-Tyr689, CF) - LS-C76015 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Rabbit
Clonality Polyclonal
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