STAT2

Gene Symbol	STAT2
Entrez Gene	6773
Alt Symbol	ISGF-3, P113, STAT113
Species	Human
Gene Type	protein-coding
Description	signal transducer and activator of transcription 2, 113kDa
Other Description	interferon alpha induced transcriptional activator|signal transducer and activator of transcription 2|signal transducer and activator of transcription 2, 113kD
Swissprots	Q16431 G3V2M6 Q16430 B4DLC7 P52630 Q9UDL4
Accessions	AAA98760 AAB36225 AAB36226 AAB36227 AAS00091 AFM91190 AFM91191 AFM91192 AFM91193 AFM91194 AFM91195 AFM91196 AFM91197 AFM91198 AFM91199 AFM91200 AFM91201 AFM91202 AFM91203 AFM91204 AFM91205 AFM91206 AFM91207 AFM91208 AFM91209 AFM91210 AFM91211 AFM91212 AFM91213 AFM91214 AFM91215 AFM91216 AFM91217 AFM91218 AFM91219 AFM91220 AFM91221 AFM91222 AFM91223 AFM91224 AFM91225 AFM91226 AFM91227 AFM91228 AFM91229 AFM91230 AFM91231 AFM91232 AFM91233 AFM91234 AFM91235 AFM91236 AFM91237 AFM91238 AFM91239 AFM91240 AFM91241 AFM91242 AFM91243 AFM91244 AFM91245 AFM91246 AFM91247 AFM91248 AFM91249 AFM91250 AFM91251 AFM91252 AFM91253 AFM91254 AFM91255 AFM91256 AFM91257 AFM91258 AFM91259 AFM91260 AFM91261 AFM91262 AFM91263 AFM91264 AFM91265 AFM91266 AFM91267 AFM91268 AFM91269 AFM91270 AFM91271 AFM91272 AFM91273 AFM91274 AFM91275 AFM91276 AFM91277 AFM91278 AFM91279 AFM91280 CAM91176 EAW96934 EAW96935 EAW96936 EAW96937 P52630 AK094039 AK295052 BAG58101 AK295114 BAG58143 AK296939 BAG59489 AK296940 BAG59490 AK308051 AK310727 AK316516 BAH14887 BC006092 AAH06092 BC051284 AAH51284 BX640607 CAE45713 CD684210 DB482283 M97934 XM_005269110 XP_005269167 XM_005269111 XP_005269168 XM_011538697 XP_011536999 XM_011538698 XP_011537000 XM_011538699 XP_011537001 XM_011538700 XP_011537002 XM_011538701 XP_011537003 XM_011538702 XP_011537004 XR_245953 XR_245954 NM_005419 NP_005410 NM_198332 NP_938146
Function	Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. {ECO:0000269|PubMed:9020188}.
Subcellular Location	Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
Top Pathways	Jak-STAT signaling pathway, Chemokine signaling pathway, Hepatitis C, Osteoclast differentiation, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

STAT2 - MBS1276398 from MyBioSource Species Human Accession BC051284

Human STAT2 cDNA clone(NM_198332.1) - CDFG012574 from Creative Biomart Species Human Accession NM_198332.1

Human STAT2 ORF Clone(NM_005419.3) - CDCL177263 from Creative Biomart Species Human Accession NM_005419.3

Human STAT2 ORF Clone(NM_198332.1) - CDCR325796 from Creative Biomart Species Human Accession NM_198332.1

Human STAT2 ORF Clone(NM_198332.1) - CDCR325797 from Creative Biomart Species Human Accession NM_198332.1

human STAT2 ORF clone - CDCH086678 from Creative Biomart Species Human Accession NM_005419

human STAT2 ORF clone - CDCH086679 from Creative Biomart Species Human Accession NM_005419

human STAT2 ORF clone - CDCH086680 from Creative Biomart Species Human Accession NM_005419

human STAT2 ORF clone - CDCH086681 from Creative Biomart Species Human Accession NM_005419

Human STAT2 Gene ORF cDNA clone in cloning vector - HG10547-M from Sino Biological Species Human

Human STAT2 Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG10547-M-N from Sino Biological Species Human Accession NM_005419.2

Human STAT2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10547-ACR from Sino Biological Species Human

Human STAT2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10547-ANR from Sino Biological Species Human

Human STAT2 Gene ORF cDNA clone expression plasmid - HG10547-UT from Sino Biological Species Human

Human STAT2 Gene ORF cDNA clone expression plasmid, N-His tag - HG10547-NH from Sino Biological Species Human

Human STAT2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10547-ACG from Sino Biological Species Human

Human STAT2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10547-NF from Sino Biological Species Human

Human STAT2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10547-NM from Sino Biological Species Human

Human STAT2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10547-CY from Sino Biological Species Human

Human STAT2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10547-CF from Sino Biological Species Human

Human STAT2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10547-ANG from Sino Biological Species Human

Human STAT2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10547-NY from Sino Biological Species Human

Human STAT2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10547-CM from Sino Biological Species Human

Human STAT2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10547-M-F from Sino Biological Species Human

Human STAT2 Gene ORF cDNA clone expression plasmid, C-His tag - HG10547-CH from Sino Biological Species Human

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