| Gene Symbol | STAT2 |
|---|---|
| Entrez Gene | 6773 |
| Alt Symbol | ISGF-3, P113, STAT113 |
| Species | Human |
| Gene Type | protein-coding |
| Description | signal transducer and activator of transcription 2, 113kDa |
| Other Description | interferon alpha induced transcriptional activator|signal transducer and activator of transcription 2|signal transducer and activator of transcription 2, 113kD |
| Swissprots | Q16431 G3V2M6 Q16430 B4DLC7 P52630 Q9UDL4 |
| Accessions | AAA98760 AAB36225 AAB36226 AAB36227 AAS00091 AFM91190 AFM91191 AFM91192 AFM91193 AFM91194 AFM91195 AFM91196 AFM91197 AFM91198 AFM91199 AFM91200 AFM91201 AFM91202 AFM91203 AFM91204 AFM91205 AFM91206 AFM91207 AFM91208 AFM91209 AFM91210 AFM91211 AFM91212 AFM91213 AFM91214 AFM91215 AFM91216 AFM91217 AFM91218 AFM91219 AFM91220 AFM91221 AFM91222 AFM91223 AFM91224 AFM91225 AFM91226 AFM91227 AFM91228 AFM91229 AFM91230 AFM91231 AFM91232 AFM91233 AFM91234 AFM91235 AFM91236 AFM91237 AFM91238 AFM91239 AFM91240 AFM91241 AFM91242 AFM91243 AFM91244 AFM91245 AFM91246 AFM91247 AFM91248 AFM91249 AFM91250 AFM91251 AFM91252 AFM91253 AFM91254 AFM91255 AFM91256 AFM91257 AFM91258 AFM91259 AFM91260 AFM91261 AFM91262 AFM91263 AFM91264 AFM91265 AFM91266 AFM91267 AFM91268 AFM91269 AFM91270 AFM91271 AFM91272 AFM91273 AFM91274 AFM91275 AFM91276 AFM91277 AFM91278 AFM91279 AFM91280 CAM91176 EAW96934 EAW96935 EAW96936 EAW96937 P52630 AK094039 AK295052 BAG58101 AK295114 BAG58143 AK296939 BAG59489 AK296940 BAG59490 AK308051 AK310727 AK316516 BAH14887 BC006092 AAH06092 BC051284 AAH51284 BX640607 CAE45713 CD684210 DB482283 M97934 XM_005269110 XP_005269167 XM_005269111 XP_005269168 XM_011538697 XP_011536999 XM_011538698 XP_011537000 XM_011538699 XP_011537001 XM_011538700 XP_011537002 XM_011538701 XP_011537003 XM_011538702 XP_011537004 XR_245953 XR_245954 NM_005419 NP_005410 NM_198332 NP_938146 |
| Function | Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. {ECO:0000269|PubMed:9020188}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta. |
| Top Pathways | Jak-STAT signaling pathway, Chemokine signaling pathway, Hepatitis C, Osteoclast differentiation, Measles |
Human/Rat STAT2 ELISA Kit (Cell-Based ELISA) - LS-F2327 from LifeSpan Bioscience
|
||||||||||
Human STAT2 ELISA Kit (Sandwich ELISA) - LS-F4985 from LifeSpan Bioscience
|
||||||||||
Human/Rat STAT2 ELISA Kit (DNA-Binding ELISA) - LS-F818 from LifeSpan Bioscience
|
||||||||||
Human/Rat Phospho-STAT2 (Tyr690) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1103 from LifeSpan Bioscience
|
||||||||||
Human Phospho-STAT2 (Y689) Cell-Based ELISA - KCB2890 from R&D Systems
|
||||||||||
Signal Transducer And Activator Of Transcription 1 (STAT1), Human, ELISA Kit - SEB740Hu from ARP American Research Products
|
||||||||||
Signal transducer and activator of transcription 1, STAT1, Human, ELISA Kit - CSB-E11755h from ARP American Research Products
|
||||||||||
Signal Transducer And Activator Of Transcription 2 (STAT2), Human, ELISA Kit - SEB796Hu from ARP American Research Products
|
||||||||||
Signal Transducer And Activator Of Transcription 2, Human, ELISA Kit - E01S0201 from ARP American Research Products
|
||||||||||
Signal transducer and activator of transcription 2, STAT2, Human, ELISA Kit - E1796h from ARP American Research Products
|
||||||||||
Signal Transducer and Activator of Transcription 2, STAT2, Human, ELISA Kit - E-EL-H2131 from ARP American Research Products
|
||||||||||
Signal Transducer And Activator Of Transcription 2, STAT2, Mouse, ELISA Kit - E-EL-M1056 from ARP American Research Products
|
||||||||||
Signal Transducer and Activator of Transcription 2, STAT2, Rabbit, ELISA Kit - E-EL-RB0913 from ARP American Research Products
|
||||||||||
Signal Transducer and Activator of Transcription 2, STAT2, Chicken, ELISA Kit - E-EL-Ch0173 from ARP American Research Products
|
||||||||||
Signal Transducer and Activator of Transcription 2, STAT2, Porcine, ELISA Kit - E-EL-P0457 from ARP American Research Products
|
||||||||||
Signal Transducer and Activator of Transcription 2, STAT2, Sheep, ELISA Kit - E-EL-S0093 from ARP American Research Products
|
||||||||||
Signal Transducer and Activator of Transcription 2, STAT2, Guinea Pig, ELISA Kit - E-EL-GP1092 from ARP American Research Products
|
||||||||||
Signal Transducer and Activator of Transcription 2, STAT2, Monkey, ELISA Kit - E-EL-MK2123 from ARP American Research Products
|
||||||||||
Human STAT2 ELISA Kit - HS0208 from NeoScientific
|
||||||||||
Anserine STAT2 ELISA Kit - AS0208 from NeoScientific
|
||||||||||
STAT2 Colorimetric Cell-Based ELISA Kit - CB5655 from Assay Biotechnology
|
||||||||||
STAT2 (Phospho-Tyr690) Colorimetric Cell-Based ELISA Kit - CBP1082 from Assay Biotechnology
|
||||||||||
STAT2 TFact™ DNA-Binding ELISA - TFE-7177 from Assay Biotechnology
|
||||||||||
Human STAT2(Signal Transducer and Activator of Transcription 2) ELISA Kit - E-EL-H2131 from Elabscience
|
||||||||||
Signal Transducer and Activator of Transcription 2, ELISA Kit - MBS044034 from MyBioSource
|