RAG1

Gene Symbol	RAG1
Entrez Gene	5896
Alt Symbol	RAG-1, RNF74
Species	Human
Gene Type	protein-coding
Description	recombination activating gene 1
Other Description	RING finger protein 74|V(D)J recombination-activating protein 1|recombination activating protein 1
Swissprots	Q8IY72 Q8NER2 E9PPC4 P15918
Accessions	AAG38421 AAM77798 CBX87169 EAW68118 P15918 AY235716 BC037344 AAH37344 M29474 AAA60248 XM_005253041 XP_005253098 XM_011520250 XP_011518552 XM_011520251 XP_011518553 NM_000448 NP_000439
Function	Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'- hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt,
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00820}.
Tissue Specificity	Maturing lymphoid cells.
Top Pathways	Primary immunodeficiency

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RAG1 (D36B3) Rabbit mAb - 3968 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D36B3

RAG-1 (D-5) - sc-377127 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

RAG-1 (H-300) - sc-5599 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

RAG-1 (K-20) - sc-363 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

RAG-1 (P-20) - sc-34269 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

RAG-1 (T-20) - sc-34270 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-RAG1 antibody - ab113821 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RAG1 antibody [EPRAGR1] - ab172637 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPRAGR1

Anti-RNF74 / RAG1 Antibody (clone 1D9) - LS-C169127 from LifeSpan Bioscience Prices $365.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1D9

Anti-RNF74 / RAG1 Antibody (Internal) - LS-C210173 from LifeSpan Bioscience Prices $295.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Anti-RNF74 / RAG1 Antibody (Internal) - LS-C210172 from LifeSpan Bioscience Prices $295.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Anti-RNF74 / RAG1 Antibody (Internal) - LS-C210171 from LifeSpan Bioscience Prices $295.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Anti-RNF74 / RAG1 Antibody (aa174-360) - LS-C311825 from LifeSpan Bioscience Prices $250.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RNF74 / RAG1 Antibody (aa946-995) - LS-C135124 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

RAG1 Antibody (1D9) - NBP2-37449 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1D9

RNF74 Polyclonal Antibody - bs-6941R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CD6-Antibody - AO1759a from Abgent, a WuXi AppTec company Prices $385.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 6B9

Rag1 antibody - 70R-8553 from Fitzgerald Prices $345.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

RAG1 antibody - abx011872 from Abbexa Host Mouse Clonality Monoclonal

Anti-RAG1 monoclonal antibody - DCABH-13165 from Creative Diagnostics Host Rabbit Clonality Monoclonal

RAG1 Monoclonal Antibody (1D9) - MA5-17163 from Thermo Fisher Scientific Prices $309.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1D9

RAG1 Antibody (D36B3) - A16618 from Thermo Fisher Scientific Host Rabbit Clonality Monoclonal Clone D36B3

Rag-1 - MBS648489 from MyBioSource Prices $395.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Rag-1 - MBS646482 from MyBioSource Prices $395.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Rag-1 - MBS646521 from MyBioSource Prices $395.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

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