RAG1

Gene Symbol	RAG1
Entrez Gene	5896
Alt Symbol	RAG-1, RNF74
Species	Human
Gene Type	protein-coding
Description	recombination activating gene 1
Other Description	RING finger protein 74|V(D)J recombination-activating protein 1|recombination activating protein 1
Swissprots	Q8IY72 Q8NER2 E9PPC4 P15918
Accessions	AAG38421 AAM77798 CBX87169 EAW68118 P15918 AY235716 BC037344 AAH37344 M29474 AAA60248 XM_005253041 XP_005253098 XM_011520250 XP_011518552 XM_011520251 XP_011518553 NM_000448 NP_000439
Function	Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'- hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt,
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00820}.
Tissue Specificity	Maturing lymphoid cells.
Top Pathways	Primary immunodeficiency

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RAG1 full length protein - ab159306 from Abcam Category Protein Source Wheat germ Species Human

RNF74 / RAG1 Antibody Blocking Peptide - LS-E15804 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RAG1 Protein - H00005896-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

RAG1-Antibody-C-term-Blocking-Peptide - BP19579b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Rag1 Blocking Peptide - 33R-3994 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RAG1 / RNF74 - H00005896-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

RAG1 / RNF74 - H00005896-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

RAG1 / RNF74 - H00005896-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

Recombinant Human V(D)J recombination-activating protein 1 ,partial - CSB-YP322816HU CSB-EP322816HU CSB-BP322816HU CSB-MP322816HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RAG-1 (744-1043) - sc-4380 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

V(D) J recombination-activating protein 1,partial, Recombinant Protein - MBS1139231 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RAG1 Peptide, Human - M34GP12929H from Creative Peptides Category Peptide Source Synthetic. Species Human

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