| Gene Symbol |
UGT1A3
|
| Entrez Gene |
54659
|
| Alt Symbol |
UDPGT, UDPGT 1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 1 family, polypeptide A3
|
| Other Description |
UDP glycosyltransferase 1 family, polypeptide A3|UDP-glucuronosyltransferase 1-3|UDP-glucuronosyltransferase 1-C|UDP-glucuronosyltransferase 1A3|UGT1*3
|
| Swissprots |
B8K287 P35503
|
| Accessions |
AAA92020 AAG30423 AAL73500 AAL73501 AAL73502 AAT94066 AAY32612 AAY32613 AAY32614 AAY32615 AAY32616 AAY32617 AAY32618 AAY32619 AAY32620 AAY32621 AAY32622 AAY32623 AAY32624 AAY32625 ABD60346 ABD60347 BAD12517 BAD12518 BAD12519 BAD12520 EAW71060 P35503 AY435138 AAR95639 BC166641 AAI66641 DQ364248 ABC96772 NM_019093 NP_061966
|
| Function |
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18674515}.
|
| Subcellular Location |
Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 1 but not isoform 2 is expressed in esophagus. {ECO:0000269|PubMed:18004212}.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Pentose and glucuronate interconversions, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450
|