| Gene Symbol | JAG1 |
|---|---|
| Entrez Gene | 182 |
| Alt Symbol | AGS, AHD, AWS, CD339, HJ1, JAGL1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | jagged 1 |
| Other Description | protein jagged-1 |
| Swissprots | O15122 O14902 A0AV43 P78504 E9PCF9 Q15816 B4DYR1 |
| Accessions | ACH41921 ACJ68516 ACJ68517 ACJ68518 EAX10341 P78504 AF003837 AAC51731 AF028593 AAB84053 AI268246 AK302554 BAG63823 AK312722 BAG35596 BC028007 BC098393 AAH98393 BC126205 AAI26206 BC126207 AAI26208 BF056748 HQ258535 ADR83289 U61276 AAB39007 U73936 AAC52020 U77720 AAC51323 U77914 AAC50909 Z50166 NM_000214 NP_000205 |
| Function | Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). {ECO:0000250, ECO:0000269|PubMed:18660822, ECO:0000269|PubMed:9462510}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. |
| Top Pathways | Notch signaling pathway, TNF signaling pathway |
Jagged1 CRISPR/Cas9 KO Plasmid (h) - sc-400208 from Santa Cruz Biotechnology
|
||||||||
Jagged1 HDR Plasmid (h) - sc-400208-HDR from Santa Cruz Biotechnology
|
||||||||
Jagged1 Double Nickase Plasmid (h) - sc-400208-NIC from Santa Cruz Biotechnology
|
||||||||
Jagged1 Double Nickase Plasmid (h2) - sc-400208-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Jagged1 CRISPR Activation Plasmid (h) - sc-400208-ACT from Santa Cruz Biotechnology
|
||||||||
Jagged1 CRISPR Activation Plasmid (h2) - sc-400208-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Jagged1 Lentiviral Activation Particles (h) - sc-400208-LAC from Santa Cruz Biotechnology
|
||||||||
Jagged1 Lentiviral Activation Particles (h2) - sc-400208-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Jagged1 siRNA (h) - sc-37202 from Santa Cruz Biotechnology
|
||||||||
Jagged1 shRNA Plasmid (h) - sc-37202-SH from Santa Cruz Biotechnology
|
||||||||
Jagged1 shRNA (h) Lentiviral Particles - sc-37202-V from Santa Cruz Biotechnology
|
||||||||
Jagged1 siRNA (h2) - sc-44335 from Santa Cruz Biotechnology
|
||||||||
Jagged1 shRNA Plasmid (h2) - sc-44335-SH from Santa Cruz Biotechnology
|
||||||||
Jagged1 shRNA (h2) Lentiviral Particles - sc-44335-V from Santa Cruz Biotechnology
|
||||||||
Jagged 1 RNAi - H00000182-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU033891 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1654 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1654 from Sigma-Aldrich
|
||||||||
JAG1 siRNA (Human) - CRH0128 from Cohesion Biosciences
|
||||||||
Jagged1 CRISPR/Cas9 KO Plasmid (h2) - sc-400208-KO-2 from Santa Cruz Biotechnology
|
||||||||
Jagged1 HDR Plasmid (h2) - sc-400208-HDR-2 from Santa Cruz Biotechnology
|
||||||||
JAG1, siRNA - MBS8234258 from MyBioSource
|
||||||||
shRNA set against Human Jag1 (NM_000214.2) - SHH321875 from Creative biogene
|
||||||||
shRNA set against Human JAG1(NM_000214.2) - SHL185520 from Creative biogene
|
||||||||
Human JAG1 siRNA - orb260630 from Biorbyt
|