GZMB

Gene Symbol	GZMB
Entrez Gene	3002
Alt Symbol	CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Species	Human
Gene Type	protein-coding
Description	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Other Description	C11|CTLA-1|T-cell serine protease 1-3E|cathepsin G-like 1|cytotoxic T-lymphocyte proteinase 2|cytotoxic serine protease B|fragmentin 2|fragmentin-2|granzyme B|human lymphocyte protein
Swissprots	Q9UCC1 Q8N1D2 P10144
Accessions	AAA67124 AAA75490 AAB59528 EAW66002 EAW66003 P10144 AY232654 AAP70244 AY232655 AAP70245 AY232656 AAP70246 AY372494 AAR23323 BC030195 AAH30195 BX283601 CB528665 EU176524 ABW03325 J03189 AAA36603 J04071 AAA52118 M17016 AAA36627 XM_011536685 XP_011534987 NM_004131 NP_004122
Function	This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Subcellular Location	Cytoplasmic granule {ECO:0000269|PubMed:8258716}. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
Top Pathways	Natural killer cell mediated cytotoxicity, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Type I diabetes mellitus

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GZMB-Over-expression-Lysate - LY11119a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

GZMB 293T Cell Transient Overexpression Lysate(Denatured) - H00003002-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

GZMB 293T Cell Transient Overexpression Lysate(Denatured) - H00003002-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

GZMB 293 Cell Lysate - 401220 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Granzyme B Overexpression Lysate (Denatured) - H00003002-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

Granzyme B Overexpression Lysate (Denatured) - H00003002-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Granzyme B Overexpression Lysate (Native) - NBL1-11417 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

granzyme B (h): 293T Lysate - sc-114114 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

granzyme B (h3): 293T Lysate - sc-158574 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

GZMB Over-expression Lysate Product - GWB-F6F752 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human Granzyme B / GZMB HEK293 Cell Lysate (WB positive control) - 10345-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Granzyme B Overexpression Lysate (Denatured) - H00003002-T03 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human Granzyme B Human Cells Transfected Lysate (positive control) (denatured) - orb172913 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human GZMB Knockdown Stable Cell Line - CSC-DC006795 from Creative biogene Category Cell Line Species Human

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