GZMB

Gene Symbol	GZMB
Entrez Gene	3002
Alt Symbol	CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Species	Human
Gene Type	protein-coding
Description	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Other Description	C11|CTLA-1|T-cell serine protease 1-3E|cathepsin G-like 1|cytotoxic T-lymphocyte proteinase 2|cytotoxic serine protease B|fragmentin 2|fragmentin-2|granzyme B|human lymphocyte protein
Swissprots	Q9UCC1 Q8N1D2 P10144
Accessions	AAA67124 AAA75490 AAB59528 EAW66002 EAW66003 P10144 AY232654 AAP70244 AY232655 AAP70245 AY232656 AAP70246 AY372494 AAR23323 BC030195 AAH30195 BX283601 CB528665 EU176524 ABW03325 J03189 AAA36603 J04071 AAA52118 M17016 AAA36627 XM_011536685 XP_011534987 NM_004131 NP_004122
Function	This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Subcellular Location	Cytoplasmic granule {ECO:0000269|PubMed:8258716}. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
Top Pathways	Natural killer cell mediated cytotoxicity, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Type I diabetes mellitus

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-GZMB-cDNA-Clone - DC06059 from Abgent, a WuXi AppTec company Prices $333.45 Sizes 10 µg Species Human Accession BC030195

GZMB - MBS1273885 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC030195

Human GZMB ORF Clone(NM_004131.4) - CDCL165654 from Creative Biomart Species Human Accession NM_004131.4

Human Granzyme B/GZMB Gene ORF cDNA clone in cloning vector - HG10345-M from Sino Biological Species Human

Human GZMB Gene cDNA Clone (full-length ORF Clone) - HG13352-G from Sino Biological Species Human Accession BC030195

Human GranzymeB Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG10345-M-N from Sino Biological Species Human Accession NM_004131.3

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG13352-ANG from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13352-ACR from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG13352-ANR from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, C-His tag - HG13352-G-H from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, C-His tag - HG13352-CH from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10345-NF from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, C-HA tag - HG10345-CY from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10345-NM from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10345-CF from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, N-HA tag - HG13352-NY from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13352-ACG from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, N-HA tag - HG10345-NY from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, C-His tag - HG10345-CH from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10345-CM from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, C-HA tag - HG13352-CY from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid - HG13352-UT from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10345-M-F from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10345-ACR from Sino Biological Species Human

Human Granzyme B/GZMB Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13352-NF from Sino Biological Species Human

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