GZMB

Gene Symbol GZMB
Entrez Gene 3002
Alt Symbol CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Species Human
Gene Type protein-coding
Description granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Other Description C11|CTLA-1|T-cell serine protease 1-3E|cathepsin G-like 1|cytotoxic T-lymphocyte proteinase 2|cytotoxic serine protease B|fragmentin 2|fragmentin-2|granzyme B|human lymphocyte protein
Swissprots Q9UCC1 Q8N1D2 P10144
Accessions AAA67124 AAA75490 AAB59528 EAW66002 EAW66003 P10144 AY232654 AAP70244 AY232655 AAP70245 AY232656 AAP70246 AY372494 AAR23323 BC030195 AAH30195 BX283601 CB528665 EU176524 ABW03325 J03189 AAA36603 J04071 AAA52118 M17016 AAA36627 XM_011536685 XP_011534987 NM_004131 NP_004122
Function This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Subcellular Location Cytoplasmic granule {ECO:0000269|PubMed:8258716}. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
Top Pathways Natural killer cell mediated cytotoxicity, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Type I diabetes mellitus

Granzyme B Antibody - 4275 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of recombinant mouse and human Granzyme B (5 ng) and extracts from the natural killer cell line NK-92, using Granyzme B Antibody.

granzyme B (2C5) - sc-8022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
granzyme B (2C5): sc-8022. Western blot analysis of granzyme B expression in IFN-γ-treated HL-60 whole cell lysate.

granzyme B (C-19) - sc-1968 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
granzyme B (C-19): sc-1968. Western blot analysis of granzyme B expression in CTLL-2 whole cell lysate.

granzyme B (GB7) - sc-56119 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Mouse
Clonality Monoclonal
granzyme B (GB7): sc-56119. Western blot analysis of granzyme B expression in non-transfected: sc-117752 (A) and human granzyme B transfected: sc-114114 (B) 293T whole cell lysates.

granzyme B (GRB7) - sc-73620 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Mouse
Clonality Monoclonal
granzyme B (GRB7): sc-73620. Western blot analysis of granzyme B expression in non-transfected: sc-117752 (A) and human granzyme B transfected: sc-114114 (B) 293T whole cell lysates.

pan granzyme (N-19) - sc-1969 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
pan granzyme (N-19): sc-1969. Immunoperoxi-dase staining of formalin fixed, paraffin-embedded human spleen tissue showing cytoplasmic and nuclear staining of cells in red pulp.

Anti-Granzyme B antibody - ab4059 from Abcam

Prices $401.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab4069 at 1/20 dilution staining rat spinal cord tissue sections by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). The tissue was formaldehyde fixed and blocked with serum prior to incubation with the antibody for 2 hours. A biotinylated goat anti-rabbit IgG was used as the secondary.See Abreview

Anti-Granzyme B antibody - ab53097 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab53097 stained MEF1 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab53097 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Granzyme B antibody - ab89415 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Granzyme B antibody (ab89415) at 1 µg/ml + Human pancreas lysate at 50 µg

Anti-Granzyme B antibody - ab73415 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Granzyme B antibody (ab73415) at 1 µg/mlLane 1 : Pancreas (Mouse) Tissue Lysate Lane 2 : Pancreas (Rat) Tissue Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-Granzyme B antibody [ GB11] - ab10912 from Abcam

Prices $373.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone GB11

Anti-Granzyme B antibody [11F1] - ab49816 from Abcam

Host Mouse
Clonality Monoclonal
Clone 11F1
Immunohistochemical staining of Hodgkin's disease (Paraffin section) for granzyme B using ab49816. Note granular cytoplasmic staining in a number of Reed Sternberg cells.

Anti-Granzyme B antibody [4E6] - ab139354 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E6
All lanes : Anti-Granzyme B antibody [4E6] (ab139354) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Granzyme B cDNALysates/proteins at 5 µg per lane.

Anti-Granzyme B antibody [B18.1.] (FITC) - ab17929 from Abcam

Prices $385.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone B18.1.
Detection of granzyme B in permeabilized human CD8+ T lymphocytes (filled profile). Isotype control in combination with a secondary FITC-labeled antibody is shown as control.Method: Permeabilized human T cells (5 x 105) were incubated on ice for 30 min in 50 µl FACS buffer (PBS, 5% Fetal calf serum, 0.02% azide) containing 1µg of FITC- labelled ab17929 antibody. After washing in FACS buffer, cells were anlyzed by flow cytometry.

Anti-Granzyme B antibody [CLB-GB11] - ab103159 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone CLB-GB11

Anti-Granzyme B antibody [EPR8260] - ab134933 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8260
Immunohistochemical analysis of paraffin-embedded, formalin-fixed Human Hodgkin's lymphoma tissue, labelling Granzyme B using ab134933 at a 1/100 dilution.

Anti-Granzyme B antibody [GM4C1] - ab26288 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone GM4C1

Anti-Granzyme B antibody [GZB01] - ab3654 from Abcam

Prices $378.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone GZB01
ab3654 - immunohistochemistry Formalin fixed paraffin embedded human Hodgkin's lymphoma with EBV stained with Granzyme B using ABC and AEC chromagen.

Anti-Granzyme B antibody [GZB01], prediluted - ab75045 from Abcam

Prices $376.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone GZB01
ab75045, at a 1/25 dilution, staining Granzyme B in formalin fixed, paraffin embedded human lymphoma tissue by Immunohistochemistry. Peroxidase conjugate and AEC chromogen were used. Note cytoplasmic staining of tumor cells.

Anti-Granzyme B antibody, prediluted - ab15313 from Abcam

Prices $382.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab15313 staining Granzyme B in human tonsil by Immunohistochemistry (FFPE-sections).

Anti-Granzyme B antibody - C-terminal - ab175509 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Granzyme B antibody - C-terminal (ab175509) at 1/1000 dilution + HL60 cell line lysate at 35 µg

Anti-GZMB / Granzyme B Antibody (clone GB7) - LS-C11635 from LifeSpan Bioscience

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone GB7

Anti-GZMB / Granzyme B Antibody - LS-C18633 from LifeSpan Bioscience

Prices $340.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GZMB / Granzyme B Antibody - LS-C18634 from LifeSpan Bioscience

Prices $395.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-GZMB / Granzyme B Antibody (N-Terminus) - LS-C24026 from LifeSpan Bioscience

Prices $325.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
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