KDM5A

Gene Symbol KDM5A
Entrez Gene 5927
Alt Symbol RBBP-2, RBBP2, RBP2
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 5A
Other Description Jumonji, AT rich interactive domain 1A (RBP2-like)|histone demethylase JARID1A|jumonji/ARID domain-containing protein 1A|lysine-specific demethylase 5A|retinoblastoma binding protein 2
Swissprots Q86XZ1 Q4LE72 A8MV76 P29375
Accessions EAW88970 EAW88971 P29375 AA101935 AB209999 BAE06081 AF007135 AK057703 AK225060 AK301150 BAG62741 AK301273 BAG62835 AK307580 AK307689 AL133026 BC048307 AAH48307 BC053893 AAH53893 BC092417 BC110916 AAI10917 BC156461 AAI56462 BC172533 AAI72533 BU182136 DA211439 DB079061 S66431 AAB28544 NM_001042603 NP_001036068 NM_005056
Function Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:7935440}. Nucleus {ECO:0000250|UniProtKB:Q3UXZ9}. Note=Occupies promoters of genes involved in RNA metabolism and mitochondrial function. {ECO:0000250|UniProtKB:Q3UXZ9}.

Jarid1A Fluorometric Assay Kit - KA1529 from Novus Biologicals

Category Assay Kit
Prices $519.00
Sizes 1 kit

Jarid1A Assay/Inhibitor Screening Assay Kit - KA1527 from Novus Biologicals

Category Assay Kit
Prices $519.00
Sizes 1 kit

Rabbit anti-JARID1A/RBP2 Antibody, Affinity Purified - PLA0152 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunofluorescence</B>: This antibody is qualified for the Proximity Ligation Assay (PLA). The above image shows representative results for PLA using three color fluorescence, including DAPI stained nuclei (blue), phalloidin stained cytoplasmic F-actin (green), and PLA positive signal (red).

Lysine-specific demethylase 5A (KDM5A), Human, ELISA Kit - CSB-EL012141HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

lysine (K) -specific demethylase 5A, ELISA Kit - MBS938758 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human KDM5A is typically less than 5.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 23.5 pg/ml -1500 pg/ml.

Human Lysine-specific demethylase 5A(KDM5A) ELISA kit - CSB-EL012141HU from Cusabio

Category ELISA Kit
Sensitivity 5.8pg/ml
Range 23.5 pg/ml-1500 pg/ml

Human Lysine-specific demethylase 5A (KDM5A) ELISA Kit - EKC34495 from Biomatik

Category ELISA Kit
Prices $705.00, $2,820.00, $5,288.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 5.8 pg/ml
Range 23.5 pg/ml-1500 pg/ml

Human KDM5A ELISA Kit - E023198 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of human KDM5A is typically less than 5.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

Human RBP2 ELISA Kit - E033388 from Biobool

Category ELISA Kit
Sensitivity 0.039 ng/ml

KDM5A ELISA Kit (Human) (OKCA00717) - OKCA00717 from Aviva Systems Biology

Category ELISA Kit
Prices $590.00
Sizes 96 wells
Sensitivity 5.8 pg/mL
Range 23.5 pg/mL-1,500 pg/mL
Search more