KDM5A

Gene Symbol	KDM5A
Entrez Gene	5927
Alt Symbol	RBBP-2, RBBP2, RBP2
Species	Human
Gene Type	protein-coding
Description	lysine (K)-specific demethylase 5A
Other Description	Jumonji, AT rich interactive domain 1A (RBP2-like)|histone demethylase JARID1A|jumonji/ARID domain-containing protein 1A|lysine-specific demethylase 5A|retinoblastoma binding protein 2
Swissprots	Q86XZ1 Q4LE72 A8MV76 P29375
Accessions	EAW88970 EAW88971 P29375 AA101935 AB209999 BAE06081 AF007135 AK057703 AK225060 AK301150 BAG62741 AK301273 BAG62835 AK307580 AK307689 AL133026 BC048307 AAH48307 BC053893 AAH53893 BC092417 BC110916 AAI10917 BC156461 AAI56462 BC172533 AAI72533 BU182136 DA211439 DB079061 S66431 AAB28544 NM_001042603 NP_001036068 NM_005056
Function	Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:7935440}. Nucleus {ECO:0000250|UniProtKB:Q3UXZ9}. Note=Occupies promoters of genes involved in RNA metabolism and mitochondrial function. {ECO:0000250|UniProtKB:Q3UXZ9}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human KDM5A / Jarid1A / RBBP2 protein fragment - ab198108 from Abcam Category Protein Prices $1,281.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human KDM5A / Jarid1A / RBBP2 peptide - ab28892 from Abcam Category Peptide

Human KDM5A / Jarid1A / RBBP2 protein fragment - ab112347 from Abcam Category Protein Source Wheat germ Species Human

RBP2 / CRBPII Antibody Blocking Peptide - LS-E23236 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RBP2 / CRBPII Antibody Blocking Peptide - LS-E10192 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RBP2 Recombinant Protein - H00005948-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RBP2 Partial Recombinant Protein - H00005948-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Jarid1A Partial Recombinant Protein - H00005927-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RBP2 Protein - NBP2-23413 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

JARID1A-Antibody-C-term-Blocking-peptide - BP12258b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human KDM5A protein - orb245896 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human RBP2 protein - orb191145 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli Species Human

Human KDM5A protein - orb244320 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

KDM5A / JARID1A - H00005927-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KDM5A / JARID1A - H00005927-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant JARID1A / KDM5A protein - 31431 from ActiveMotif Category Protein Prices $395.00, $3,800.00 Sizes 20 μg, 1 mg Source Baculovirus Species Human

Recombinant Human KDM5A - KDM5A-29894TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human KDM5A, FLAG-tagged - KDM5A-43H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Human Lysine-specific demethylase 5A(KDM5A) ,partial - CSB-YP012141HU CSB-BP012141HU CSB-MP012141HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant Human Lysine-specific demethylase 5A(KDM5A) ,partial - CSB-EP012141HU from Cusabio Category Protein Source Yeast Species Human

Lysine-specific demethylase 5A Protein - abx163403 from Abbexa Category Protein Species Human, Mouse, Rat

KDM5A / JARID1A (full length, C-term DDK tag) - TP710232 from Acris Antibodies Category Protein Prices $399.00 Sizes 20 µg Species Human

Jarid1A Protein - NBP1-87802PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

RBP2 Recombinant Protein Antigen - NBP1-85464PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

JARID1A-Antibody-N-term-Blocking-Peptide - BP1192a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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