| Gene Symbol |
KDM5A
|
| Entrez Gene |
5927
|
| Alt Symbol |
RBBP-2, RBBP2, RBP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysine (K)-specific demethylase 5A
|
| Other Description |
Jumonji, AT rich interactive domain 1A (RBP2-like)|histone demethylase JARID1A|jumonji/ARID domain-containing protein 1A|lysine-specific demethylase 5A|retinoblastoma binding protein 2
|
| Swissprots |
Q86XZ1 Q4LE72 A8MV76 P29375
|
| Accessions |
EAW88970 EAW88971 P29375 AA101935 AB209999 BAE06081 AF007135 AK057703 AK225060 AK301150 BAG62741 AK301273 BAG62835 AK307580 AK307689 AL133026 BC048307 AAH48307 BC053893 AAH53893 BC092417 BC110916 AAI10917 BC156461 AAI56462 BC172533 AAI72533 BU182136 DA211439 DB079061 S66431 AAB28544 NM_001042603 NP_001036068 NM_005056
|
| Function |
Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:7935440}. Nucleus {ECO:0000250|UniProtKB:Q3UXZ9}. Note=Occupies promoters of genes involved in RNA metabolism and mitochondrial function. {ECO:0000250|UniProtKB:Q3UXZ9}.
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