| Gene Symbol | ID2 |
|---|---|
| Entrez Gene | 3398 |
| Alt Symbol | GIG8, ID2A, ID2H, bHLHb26 |
| Species | Human |
| Gene Type | protein-coding |
| Description | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
| Other Description | DNA-binding protein inhibitor ID-2|DNA-binding protein inhibitor ID2|cell growth-inhibiting gene 8|class B basic helix-loop-helix protein 26|helix-loop-helix protein ID2|inhibitor of differentiation 2 |
| Swissprots | Q02363 |
| Accessions | AAY14810 EAX01018 EAX01019 Q02363 AK222682 BAD96402 AK311988 BAG34927 AY634687 AAV35470 BC030639 AAH30639 BE222494 D13891 BAA02990 DQ890858 ABM81784 DQ894013 ABM84939 M97796 AAA58681 NM_002166 NP_002157 |
| Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. {ECO:0000269|PubMed:20861012}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:20861012}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:20861012}. |
| Tissue Specificity | Highly expressed in early fetal tissues, including those of the central nervous system. |
| Top Pathways | TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer |