ID2

Gene Symbol	ID2
Entrez Gene	3398
Alt Symbol	GIG8, ID2A, ID2H, bHLHb26
Species	Human
Gene Type	protein-coding
Description	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Other Description	DNA-binding protein inhibitor ID-2|DNA-binding protein inhibitor ID2|cell growth-inhibiting gene 8|class B basic helix-loop-helix protein 26|helix-loop-helix protein ID2|inhibitor of differentiation 2
Swissprots	Q02363
Accessions	AAY14810 EAX01018 EAX01019 Q02363 AK222682 BAD96402 AK311988 BAG34927 AY634687 AAV35470 BC030639 AAH30639 BE222494 D13891 BAA02990 DQ890858 ABM81784 DQ894013 ABM84939 M97796 AAA58681 NM_002166 NP_002157
Function	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. {ECO:0000269|PubMed:20861012}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:20861012}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:20861012}.
Tissue Specificity	Highly expressed in early fetal tissues, including those of the central nervous system.
Top Pathways	TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ID2 full length protein - ab112306 from Abcam Category Protein Source Wheat germ Species Human

Human ID2 full length protein - ab140586 from Abcam Category Protein Source E. coli Species Human

ID2 Antibody Blocking Peptide - LS-E10923 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ID2 Protein - H00003398-P01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

ID2 Partial Recombinant Protein - H00003398-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ID2 Protein - NBP2-23139 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

ID2 Protein - GTX109113-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

Human ID2 protein - orb168539 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Human ID2 protein - orb244284 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

ID2 protein (His tag) - 80R-2695 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

ID2 / BHLHB26 (1-134, His-tag) - AR50815PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

ID2 / BHLHB26 (1-134, His-tag) - AR50815PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

ID2 / BHLHB26 - H00003398-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ID2 / BHLHB26 - H00003398-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ID2 / BHLHB26 - H00003398-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ID2 / BHLHB26 - H00003398-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ID2, 1-134aa, Human, His tag, E.coli - 01-P1991 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

ID2 fusion protein - ag3179 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ID2 Human - PRPS-1390 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source E.coli. Species Human

Recombinant Human ID2 - ID2-28380TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human ID2, His-tagged - ID2-7547H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human DNA-binding protein inhibitor ID-2 - CSB-YP010967HU CSB-BP010967HU CSB-MP010967HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant Human DNA-binding protein inhibitor ID-2 - CSB-EP010967HU from Cusabio Category Protein Source E.coli Species Human

ID2, 1-134aa, Human, His tag, E.coli (Denatured) - ATGP1991 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

ID2 / BHLHB26 - TP305324 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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