ID2

Gene Symbol	ID2
Entrez Gene	3398
Alt Symbol	GIG8, ID2A, ID2H, bHLHb26
Species	Human
Gene Type	protein-coding
Description	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Other Description	DNA-binding protein inhibitor ID-2|DNA-binding protein inhibitor ID2|cell growth-inhibiting gene 8|class B basic helix-loop-helix protein 26|helix-loop-helix protein ID2|inhibitor of differentiation 2
Swissprots	Q02363
Accessions	AAY14810 EAX01018 EAX01019 Q02363 AK222682 BAD96402 AK311988 BAG34927 AY634687 AAV35470 BC030639 AAH30639 BE222494 D13891 BAA02990 DQ890858 ABM81784 DQ894013 ABM84939 M97796 AAA58681 NM_002166 NP_002157
Function	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. {ECO:0000269|PubMed:20861012}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:20861012}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:20861012}.
Tissue Specificity	Highly expressed in early fetal tissues, including those of the central nervous system.
Top Pathways	TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Id2 CRISPR/Cas9 KO Plasmid (h) - sc-400550 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Id2 HDR Plasmid (h) - sc-400550-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Id2 Double Nickase Plasmid (h) - sc-400550-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Id2 Double Nickase Plasmid (h2) - sc-400550-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Id2 CRISPR Activation Plasmid (h) - sc-400550-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Id2 CRISPR Activation Plasmid (h2) - sc-400550-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Id2 Lentiviral Activation Particles (h) - sc-400550-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Id2 Lentiviral Activation Particles (h2) - sc-400550-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Id2 siRNA (h) - sc-38000 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Id2 shRNA Plasmid (h) - sc-38000-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Id2 shRNA (h) Lentiviral Particles - sc-38000-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Id2 siRNA (h2) - sc-63296 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

Id2 shRNA Plasmid (h2) - sc-63296-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

Id2 shRNA (h2) Lentiviral Particles - sc-63296-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

ID2 RNAi - H00003398-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ID2 RNAi - H00003398-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU119651 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10437 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10437 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

ID2 siRNA (Human) - CRH2308 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ID2 - MBS8213724 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ID2 (NM_002166.4) - SHH316509 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human ID2(NM_002166.4) - SHL164568 from Creative biogene Category siRNA Species Reactivities Human

Human ID2 siRNA - orb262810 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ID2 shRNA Plasmid (Human) - CHH2308 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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