IPO8

Gene Symbol IPO8
Entrez Gene 10526
Alt Symbol RANBP8
Species Human
Gene Type protein-coding
Description importin 8
Other Description RAN binding protein 8|imp8|importin-8|ran-binding protein 8
Swissprots O15397 B7Z7M3
Accessions EAW96607 O15397 AA620453 AB209602 BAD92839 AK000201 AK025607 AK130090 AK302260 BAH13659 AU132276 BC167853 AAI67853 BF947771 BG574795 BQ435282 BX953637 DB067822 DB072643 DB088518 DC400226 EB387074 U77494 AAB67052 XM_011520546 XP_011518848 XM_011520547 XP_011518849 XM_011520548 XP_011518850 XM_011520549 XP_011518851 NM_001190995 NP_001177924 NM_006390 NP_006381
Function Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9214382}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Importin-8 (C-5) - sc-398854 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Importin-8 (C-5): sc-398854. Western blot analysis of Importin-8 expression in NTERA-2 cl.D1 (A), HeLa (B) and HEK293 (D) whole cell lysates and HeLa nuclear extract (C).

Importin-8 (H-59) - sc-367674 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Importin-8 (N-18) - sc-74668 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Importin-8 (N-18): sc-74668. Western blot analysis of Importin-8 expression in K-562 nuclear extract.

Anti-Importin 8 antibody - ab198818 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue labeling Importin 8 with ab198818 at a 1/50 dilution.

Anti-Importin 8 antibody - ab5263 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab5263 (4µg/ml) staining of paraffin embedded Human Tonsil shows cytoplam staining in the parenchyma. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.

Anti-Importin 8 antibody - ab72109 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Importin 8 antibody (ab72109) at 1 µg/mlLane 1 : HeLa cell lysateLane 2 : HeLa cell lysate with immunizing peptide

Anti-IPO8 / Importin 8 Antibody (aa850-900) - LS-C47292 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC staining of HeLa cells using control (Rabbit Ig) at 5 ug/ml.

Anti-IPO8 / Importin 8 Antibody (aa74-104) - LS-C165266 from LifeSpan Bioscience

Prices $250.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IPO8 Antibody (N-term) IHC of formalin fixed and paraffin embedded human cervix carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This demonstrates the use of the IPO8 Antibody (N-term) for immunohistochemistry.

Anti-IPO8 / Importin 8 Antibody (aa1026-1037) - LS-C55362 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-IPO8 / Importin 8 Antibody (aa646-695) - LS-C152074 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IPO8 / Importin 8 antibody Western Blot of Fetal Kidney.

Anti-IPO8 / Importin 8 Antibody (aa987-1037) - LS-C286083 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human RanBP8 by Western Blot. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug) and 293T (T; 50 ug) cells. Antibody: Affinity purified rabbit anti-RanBP8 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-IPO8 / Importin 8 Antibody (aa417-622) - LS-C314430 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IPO8 / Importin 8.

Importin-8 Antibody - NBP2-24751 from Novus Biologicals

Prices $99.00, $299.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Importin-8 Antibody - NBP1-87878 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Importin-8 Antibody - NB100-1072 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry-Paraffin: Importin-8 Antibody [NB100-1072] - Staining of Human Tonsil. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. Similar results were obtained after antigen retrieval at pH9. (4ug/ml)

Importin-8 Antibody - NB100-94994 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Importin-8 Antibody [NB100-94994] - Whole cell lysate from HeLa (5, 15 and 50 ug) and 293T (T; 50 ug) cells. Antibody used at for WB at 0.4 ug/ml.

Importin-8 Antibody - NBP1-87879 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Importin-8 Antibody [NBP1-87879] - Staining of human kidney shows moderate granular cytoplasmic positivity in tubular cells.

Importin-8 Antibody (3D5) - H00010526-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D5
Western Blot: Importin-8 Antibody (3D5) [H00010526-M01] - IPO8 monoclonal antibody (M01), clone 3D5. Analysis of IPO8 expression in Hela S3 NE.

Anti-IPO8 antibody produced in rabbit - HPA023765 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-IPO8: <B>Cat. No. HPA023765</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in subsets of cells.

Anti-IPO8 (C-terminal) antibody produced in goat - SAB2501875 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-IPO8 (C-terminal): <B>Cat. No. SAB2501875</B>: (4 μg/mL) staining of paraffin embedded Human Tonsil. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. Similar results were obtained after antigen retrieval at pH 9.

Anti-IPO8 antibody produced in rabbit - HPA018439 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-IPO8: <B>Cat. No. HPA018439</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human gall bladder shows cytoplasmic positivity with a granular pattern in glandular cells.

IPO8 Antibody - C-terminal region (ARP65771_P050) - ARP65771_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RANBP8--IPO8-Antibody-C-Term - AF2272a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2272a (4 µg/ml) staining of paraffin embedded Human Tonsil. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. Similar results were obtained after antigen retrieval at pH9.

Importin-8 antibody [C3], C-term - GTX106407 from GeneTex

Host Rabbit
Clonality Polyclonal

Goat Anti-RANBP8 / IPO8 Antibody (OAEB00010) - OAEB00010 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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