IPO8

Gene Symbol	IPO8
Entrez Gene	10526
Alt Symbol	RANBP8
Species	Human
Gene Type	protein-coding
Description	importin 8
Other Description	RAN binding protein 8|imp8|importin-8|ran-binding protein 8
Swissprots	O15397 B7Z7M3
Accessions	EAW96607 O15397 AA620453 AB209602 BAD92839 AK000201 AK025607 AK130090 AK302260 BAH13659 AU132276 BC167853 AAI67853 BF947771 BG574795 BQ435282 BX953637 DB067822 DB072643 DB088518 DC400226 EB387074 U77494 AAB67052 XM_011520546 XP_011518848 XM_011520547 XP_011518849 XM_011520548 XP_011518850 XM_011520549 XP_011518851 NM_001190995 NP_001177924 NM_006390 NP_006381
Function	Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9214382}.
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Importin 8 peptide - ab23081 from Abcam Category Peptide Species Human

Human Importin 8 protein fragment - ab153095 from Abcam Category Protein Source Wheat germ Species Human

IPO8 / Importin 8 Antibody Blocking Peptide - LS-E25393 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IPO8 / Importin 8 Antibody Blocking Peptide - LS-E23941 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Importin-8 Protein - H00010526-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Importin 8 blocking peptide - GTX25263-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Importin 8 Peptide - AC21-0221-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RanBP8 / Importin-8 - H00010526-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RanBP8 / Importin-8 - H00010526-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Importin 8 Peptide - 45-771P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Importin 8 (IPO8) - RPA206Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Human Importin-8(IPO8) ,partial - CSB-YP011780HU CSB-EP011780HU CSB-BP011780HU CSB-MP011780HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RANBP8/IPO8, Peptide - MBS425737 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog, Pig, Bovine

Importin-8 Recombinant Protein Antigen - NBP1-87879PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Importin-8 Recombinant Protein Antigen - NBP1-87878PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

IPO8-Blocking-Peptide-N-term - BP5435a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IPO8 Peptide, Human - M34GP07706H from Creative Peptides Category Peptide Source Synthetic. Species Human

Importin 8, Recombinant Protein - MBS2030782 from MyBioSource Category Protein Prices $195.00, $420.00, $650.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

Importin-8 (IPO8), partial, Recombinant Protein - MBS1035870 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

IPO8 Immunizing peptide - orb17441 from Biorbyt Category Peptide

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