IPO8
| Gene Symbol | IPO8 |
|---|---|
| Entrez Gene | 10526 |
| Alt Symbol | RANBP8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | importin 8 |
| Other Description | RAN binding protein 8|imp8|importin-8|ran-binding protein 8 |
| Swissprots | O15397 B7Z7M3 |
| Accessions | EAW96607 O15397 AA620453 AB209602 BAD92839 AK000201 AK025607 AK130090 AK302260 BAH13659 AU132276 BC167853 AAI67853 BF947771 BG574795 BQ435282 BX953637 DB067822 DB072643 DB088518 DC400226 EB387074 U77494 AAB67052 XM_011520546 XP_011518848 XM_011520547 XP_011518849 XM_011520548 XP_011518850 XM_011520549 XP_011518851 NM_001190995 NP_001177924 NM_006390 NP_006381 |
| Function | Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9214382}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Importin-8 CRISPR/Cas9 KO Plasmid (h) - sc-405383 from Santa Cruz Biotechnology
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Importin-8 HDR Plasmid (h) - sc-405383-HDR from Santa Cruz Biotechnology
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Importin-8 Double Nickase Plasmid (h) - sc-405383-NIC from Santa Cruz Biotechnology
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Importin-8 Double Nickase Plasmid (h2) - sc-405383-NIC-2 from Santa Cruz Biotechnology
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Importin-8 CRISPR Activation Plasmid (h) - sc-405383-ACT from Santa Cruz Biotechnology
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Importin-8 CRISPR Activation Plasmid (h2) - sc-405383-ACT-2 from Santa Cruz Biotechnology
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Importin-8 Lentiviral Activation Particles (h) - sc-405383-LAC from Santa Cruz Biotechnology
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Importin-8 Lentiviral Activation Particles (h2) - sc-405383-LAC-2 from Santa Cruz Biotechnology
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Importin-8 siRNA (h) - sc-75336 from Santa Cruz Biotechnology
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Importin-8 shRNA Plasmid (h) - sc-75336-SH from Santa Cruz Biotechnology
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Importin-8 shRNA (h) Lentiviral Particles - sc-75336-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU000261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10734 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10734 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10462 from Sigma-Aldrich
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IPO8 siRNA (Human) - CRH7153 from Cohesion Biosciences
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Importin-8 RNAi - H00010526-R01 from Novus Biologicals
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IPO8 - MBS8213577 from MyBioSource
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shRNA set against Human IPO8 (NM_006390.3) - SHH320201 from Creative biogene
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Human IPO8 siRNA - orb267655 from Biorbyt
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IPO8 shRNA Plasmid (Human) - CHH7153 from Cohesion Biosciences
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IPO8 miRNA 3'UTR clone - MiUTR3H-07819 from Creative biogene
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