PLK3

Gene Symbol PLK3
Entrez Gene 1263
Alt Symbol CNK, FNK, PRK
Species Human
Gene Type protein-coding
Description polo-like kinase 3
Other Description FGF-inducible kinase|PLK-3|cytokine-inducible kinase|cytokine-inducible serine/threonine-protein kinase|proliferation-related kinase|serine/threonine-protein kinase PLK3
Swissprots Q9H4B4 Q5JR99 Q15767 Q96CV1
Accessions AAU88146 EAX07021 Q9H4B4 AA421212 AB209875 BAD93112 AJ293866 CAC10659 BC004135 BC004198 BC013899 AAH13899 BC013960 EU832631 ACE87722 EU832706 ACE87038 U56998 AAC50637 XR_246234 XR_946541 NM_004073 NP_004064
Function Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 i
Subcellular Location Cytoplasm. Nucleus. Nucleus, nucleolus. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Translocates to the nucleus upon cisplatin treatment. Localizes to the Golgi apparatus during interphase. According to a report, PLK3 localizes only in the nucleolus and not in the centrosome, or in any other location in the cytoplasm (PubMed:17264206). The discrepancies in results may be explained by the PLK3 antibody specificity, by cell line- specific expression or post-translational modifications. {ECO:0000269|PubMed:17264206}.
Tissue Specificity Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor.
Top Pathways Tuberculosis

PLK3 (D14F12) Rabbit mAb - 4896 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D14F12
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a human PLK3 construct (+), using PLK3 (D14F12) Rabbit mAb.

Fnk (H-140) - sc-25422 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Fnk (H-140): sc-25422. Western blot analysis of Fnk expression in mouse lung tissue extract.

Fnk (N-19) - sc-9578 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Fnk (C-20) - sc-9580 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PLK3 antibody - ab175102 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-PLK3 antibody (ab175102) at 3 µg/ml + HeLa lysate at 35 µg

Anti-PLK3 antibody - ab123695 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PLK3 antibody (ab123695) at 1/100 dilution + WiDr cell line lysates at 35 µg

Anti-PLK3 antibody - ab137952 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PLK3 antibody (ab137952) at 1/500 dilution + RAW264.7 cell lysate at 30 µg

Anti-PLK3 antibody - ab67922 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-PLK3 antibody (ab67922) at 1/2000 dilution + HeLa cell lysate at 18 µgSecondaryHRP-conjugated donkey anti-mouse IgG polyclonal at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PLK3 antibody - ab33119 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PLK3 antibody (ab33119) at 1 µg/mlLane 1 : Irradiated Hela Whole Cell Lysate Lane 2 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell Lysate Lane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PLK3 Antibody (aa320-520) - LS-C38289 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PLK3 Antibody (aa617-646, AP) - LS-C216845 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLK3 Antibody (aa221-270) - LS-C200500 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from RAW264.7cells using PLK3 antibody.

Anti-PLK3 Antibody (aa617-646, APC) - LS-C216846 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLK3 Antibody (aa617-646, Biotin) - LS-C216847 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLK3 Antibody (aa617-646, FITC) - LS-C216848 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLK3 Antibody (aa617-646, Azide-free, HRP) - LS-C216849 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLK3 Antibody (aa385-434) - LS-C135264 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PLK3 antibody LS-C135264 Western blot of Mouse Brain lysate. Antibody concentration 1 ug/ml.

Anti-PLK3 Antibody (aa617-646, PE) - LS-C216850 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLK3 Antibody (aa33-61, AP) - LS-C216851 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLK3 Antibody (aa33-61, APC) - LS-C216852 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLK3 Antibody (aa231-280) - LS-C120365 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HepG2 cells, using PLK3 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-PLK3 Antibody (aa33-61, Biotin) - LS-C216853 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLK3 Antibody (aa33-61, FITC) - LS-C216854 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLK3 Antibody (aa33-61, Azide-free, HRP) - LS-C216855 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLK3 Antibody (aa33-61, PE) - LS-C216857 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more