PLK3

Gene Symbol	PLK3
Entrez Gene	1263
Alt Symbol	CNK, FNK, PRK
Species	Human
Gene Type	protein-coding
Description	polo-like kinase 3
Other Description	FGF-inducible kinase|PLK-3|cytokine-inducible kinase|cytokine-inducible serine/threonine-protein kinase|proliferation-related kinase|serine/threonine-protein kinase PLK3
Swissprots	Q9H4B4 Q5JR99 Q15767 Q96CV1
Accessions	AAU88146 EAX07021 Q9H4B4 AA421212 AB209875 BAD93112 AJ293866 CAC10659 BC004135 BC004198 BC013899 AAH13899 BC013960 EU832631 ACE87722 EU832706 ACE87038 U56998 AAC50637 XR_246234 XR_946541 NM_004073 NP_004064
Function	Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 i
Subcellular Location	Cytoplasm. Nucleus. Nucleus, nucleolus. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Translocates to the nucleus upon cisplatin treatment. Localizes to the Golgi apparatus during interphase. According to a report, PLK3 localizes only in the nucleolus and not in the centrosome, or in any other location in the cytoplasm (PubMed:17264206). The discrepancies in results may be explained by the PLK3 antibody specificity, by cell line- specific expression or post-translational modifications. {ECO:0000269|PubMed:17264206}.
Tissue Specificity	Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor.
Top Pathways	Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PLK3 full length protein - ab42603 from Abcam Category Protein Prices $321.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human PLK3 protein fragment - ab125627 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human PLK3 full length protein - ab158149 from Abcam Category Protein Source Wheat germ Species Human

Human PLK3 peptide - ab33118 from Abcam Category Peptide

Human PLK3 protein fragment - ab196417 from Abcam Category Protein Source E. coli Species Human

PLK3 Antibody Blocking Peptide - LS-E3507 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLK3 Antibody Blocking Peptide - LS-E28067 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLK3 Antibody Blocking Peptide - LS-E9453 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLK3 Recombinant Protein - H00001263-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human PLK3 Protein - P4766 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

PLK3 Peptide - P3028 from Novus Biologicals Category Peptide Species Human

PLK3-Antibody-C-term-Blocking-Peptide - BP8044b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Plk3 Blocking Peptide - 33R-7029 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PLK3 Peptide - AC21-2938-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PLK3 - H00001263-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PLK3 - P4766 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

PLK3 - P5798 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

PLK3 fusion protein - ag1431 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PLK3, Active Human Recombinant Protein - GWB-BFCE77 from Genway Biotech Category Protein Prices $410.00 Sizes 10 µg Species Human

Recombinant Human Polo-like Kinase 3 (Drosophila), His-tagged - PLK3-566H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

Recombinant Human PLK3, His-tagged - PLK3-31032TH from Creative Biomart Category Protein

Recombinant Human PLK3, GST-tagged - PLK3-1069H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

PLK3 Protein, active, 250 µg - 14-572M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-572) and in bulk (cat# 14-572-K) Source expressed by baculovirus in Sf21 insect cells

Recombinant Human Serine/threonine-protein kinase PLK3(PLK3) - CSB-YP880972HU CSB-EP880972HU CSB-BP880972HU CSB-MP880972HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

polo-like kinase 3, Peptide - MBS427896 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

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