TNF

Gene Symbol	TNF
Entrez Gene	7124
Alt Symbol	DIF, TNF-alpha, TNFA, TNFSF2
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor
Other Description	APC1 protein|TNF, macrophage-derived|TNF, monocyte-derived|TNF-a|cachectin|tumor necrosis factor ligand superfamily member 2|tumor necrosis factor-alpha
Swissprots	Q9P1Q2 Q9UIV3 P01375 O43647
Accessions	AAA36758 AAA61200 AAB01765 AAD18091 AAL47581 AAO21132 AAV63951 AHJ25918 AHJ25919 AHJ25920 AHJ25921 AHJ25922 AHJ25923 AHJ25924 AHJ25925 BAB63396 BAC54944 BAE78639 BAF31279 CAA26669 CAA75070 CAA78745 CAB65595 CAI95946 EAX03424 P01375 AB451492 BAG70306 AF043342 AAC03542 AF098751 AAF71992 AJ227911 AJ251878 CAB63904 AJ251879 CAB63905 AK314960 BAG37464 BC028148 AAH28148 BI908079 BP215875 CA306559 DQ891662 ABM82588 DQ894849 ABM85775 FJ795028 ACO37640 HQ201306 ADV31546 M10988 AAA61198 M35592 AAC42098 X01394 CAA25650 NM_000594 NP_000585
Function	Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:23396208}.
Subcellular Location	C-domain 2: Secreted.
Top Pathways	TNF signaling pathway, Proteoglycans in cancer, Sphingolipid signaling pathway, NOD-like receptor signaling pathway, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-TNF-cDNA-Clone - DC05784 from Abgent, a WuXi AppTec company Prices $314.55 Sizes 10 µg Species Human Accession NM_000594

TNF - MBS1277357 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC028148

Human TNF ORF Clone(NM_000594.3) - CDCL179182 from Creative Biomart Species Human Accession NM_000594.3

human TNF ORF clone - CDCH093382 from Creative Biomart Species Human Accession NM_000594

human TNF ORF clone - CDCH093383 from Creative Biomart Species Human Accession NM_000594

human TNF ORF clone - CDCH093384 from Creative Biomart Species Human Accession NM_000594

human TNF ORF clone - CDCH093385 from Creative Biomart Species Human Accession NM_000594

Human TNF-alpha/TNFA/TNFSF2 Gene ORF cDNA clone in cloning vector - HG10602-M from Sino Biological Species Human

Human TNF-alpha/TNFA/TNFSF2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10602-CF from Sino Biological Species Human

Human TNF-alpha/TNFA/TNFSF2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10602-NY from Sino Biological Species Human

Human TNF-alpha/TNFA/TNFSF2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10602-CM from Sino Biological Species Human

Human TNF-alpha/TNFA/TNFSF2 Gene ORF cDNA clone expression plasmid, C-His tag - HG10602-CH from Sino Biological Species Human

Human TNF-alpha/TNFA/TNFSF2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10602-ACR from Sino Biological Species Human

Human TNF-alpha/TNFA/TNFSF2 Gene ORF cDNA clone expression plasmid - HG10602-UT from Sino Biological Species Human

Human TNF-alpha/TNFA/TNFSF2 Gene ORF cDNA clone expression plasmid, N-His tag - HG10602-NH from Sino Biological Species Human

Human TNF-alpha/TNFA/TNFSF2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10602-ACG from Sino Biological Species Human

Human TNF-alpha/TNFA/TNFSF2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10602-NF from Sino Biological Species Human

Human TNF-alpha/TNFA/TNFSF2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10602-CY from Sino Biological Species Human

Human TNF-alpha/TNFA/TNFSF2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10602-NM from Sino Biological Species Human

Human TNF ORF Clone (BC028148) - CDCS405778 from Creative biogene Species Human Accession P01375

Human TNF alpha Gene - orb91157 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Ferret TNFA Gene cDNA Clone - orb145605 from Biorbyt Prices $264.00 Sizes 10 μg

Human TNF-alpha (AAA61198) VersaClone cDNA - RDC2110 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

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