TNF

Gene Symbol	TNF
Entrez Gene	7124
Alt Symbol	DIF, TNF-alpha, TNFA, TNFSF2
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor
Other Description	APC1 protein|TNF, macrophage-derived|TNF, monocyte-derived|TNF-a|cachectin|tumor necrosis factor ligand superfamily member 2|tumor necrosis factor-alpha
Swissprots	Q9P1Q2 Q9UIV3 P01375 O43647
Accessions	AAA36758 AAA61200 AAB01765 AAD18091 AAL47581 AAO21132 AAV63951 AHJ25918 AHJ25919 AHJ25920 AHJ25921 AHJ25922 AHJ25923 AHJ25924 AHJ25925 BAB63396 BAC54944 BAE78639 BAF31279 CAA26669 CAA75070 CAA78745 CAB65595 CAI95946 EAX03424 P01375 AB451492 BAG70306 AF043342 AAC03542 AF098751 AAF71992 AJ227911 AJ251878 CAB63904 AJ251879 CAB63905 AK314960 BAG37464 BC028148 AAH28148 BI908079 BP215875 CA306559 DQ891662 ABM82588 DQ894849 ABM85775 FJ795028 ACO37640 HQ201306 ADV31546 M10988 AAA61198 M35592 AAC42098 X01394 CAA25650 NM_000594 NP_000585
Function	Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:23396208}.
Subcellular Location	C-domain 2: Secreted.
Top Pathways	TNF signaling pathway, Proteoglycans in cancer, Sphingolipid signaling pathway, NOD-like receptor signaling pathway, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalKine™ Human TNF-α Sandwich ELISA Kit - 7289 from Cell Signaling Technology Category ELISA Kit

SignalKine™ Human TNF-α Chemiluminescent Sandwich ELISA Kit - 8668 from Cell Signaling Technology Category ELISA Kit

TNF alpha Human ELISA Kit - ab46087 from Abcam Category ELISA Kit Prices $489.00, $734.00 Sizes 1 x 96 tests, 2 x 96 tests Sensitivity < 10 pg/ml Range 25 pg/ml - 800 pg/ml

TNF alpha Human ELISA Kit - ab108908 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity = 0.016 ng/ml Range 0.016 ng/ml - 1 ng/ml

TNF alpha Human ELISA Set (without plates) - ab47347 from Abcam Prices $557.00, $636.00 Sizes 5 x 96 tests, 10 x 96 tests Sensitivity < 10 pg/ml Range 25 pg/ml - 800 pg/ml

TNF alpha Human Elispot Kit - ab46566 from Abcam Category ELISA Kit Prices $937.00, $1,563.00 Sizes 5 x 96 tests, 10 x 96 tests

TNF alpha Human Elispot Kit - ab62945 from Abcam Category ELISA Kit Prices $339.00, $937.00 Sizes 1 x 96 tests, 5 x 96 tests

TNF alpha Human Elispot Kit (Reagents for 10 x 96 tests, without plates) - ab46603 from Abcam Category ELISA Kit Prices $1,021.00 Sizes 10 x 96 tests

TNF alpha Human ELISPOT Kit (without plates) - ab46550 from Abcam Category ELISA Kit Prices $729.00, $1,021.00, $1,359.00, $1,614.00 Sizes 5 x 96 tests, 10 x 96 tests, 15 x 96 tests, 20 x 96 tests

TNF alpha Human SimpleStep ELISA® Kit - ab181421 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 14 pg/ml Range 31.25 pg/ml - 2000 pg/ml

TNF alpha Human ELISA Kit - ab100654 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 30 pg/ml Range 24.58 pg/ml - 6000 pg/ml

Human Tumor Necrosis Factor α ELISA Kit - RAB0476 from Sigma-Aldrich Category ELISA Kit Prices $438.50 Sizes 1 kt

Rabbit TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F5127 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Sensitivity 3.13 pg/ml Range 3.13-200 pg/ml

Human TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F5191 from LifeSpan Bioscience Category ELISA Kit Prices $510.00 Sizes 1 plate Sensitivity 2.71 pg/ml Range 3.13-200 pg/ml

Mouse TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F5192 from LifeSpan Bioscience Category ELISA Kit Prices $520.00 Sizes 1 plate Sensitivity 15.63 pg/ml Range 3.13-200 pg/ml

Rat TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F5193 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Sensitivity 15.63 pg/ml Range 3.13-200 pg/ml

Horse TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F6022 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 2.9 pg/ml Range 3.13-200 pg/ml

Rhesus monkey TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F4818 from LifeSpan Bioscience Category ELISA Kit Prices $830.00 Sizes 1 plate Sensitivity 7.81 pg/ml Range 3.13-200 pg/ml

Bovine TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F5014 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 7.81 pg/ml Range 3.13-200 pg/ml

Dog TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F4921 from LifeSpan Bioscience Category ELISA Kit Prices $580.00 Sizes 1 plate Sensitivity 5.8 pg/ml Range 3.13-200 pg/ml

Pig TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F5347 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 6.1 pg/ml Range 3.13-200 pg/ml

Guinea pig TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F5322 from LifeSpan Bioscience Category ELISA Kit Prices $580.00 Sizes 1 plate Sensitivity 7.8 pg/ml Range 3.13-200 pg/ml

Human TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F600 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 3.13-200 pg/ml

Rat TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F632 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 3.13-200 pg/ml

Mouse TNF Alpha ELISA Kit (Sandwich ELISA) - LS-F624 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 3.13-200 pg/ml

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