TNF

Gene Symbol	TNF
Entrez Gene	7124
Alt Symbol	DIF, TNF-alpha, TNFA, TNFSF2
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor
Other Description	APC1 protein|TNF, macrophage-derived|TNF, monocyte-derived|TNF-a|cachectin|tumor necrosis factor ligand superfamily member 2|tumor necrosis factor-alpha
Swissprots	Q9P1Q2 Q9UIV3 P01375 O43647
Accessions	AAA36758 AAA61200 AAB01765 AAD18091 AAL47581 AAO21132 AAV63951 AHJ25918 AHJ25919 AHJ25920 AHJ25921 AHJ25922 AHJ25923 AHJ25924 AHJ25925 BAB63396 BAC54944 BAE78639 BAF31279 CAA26669 CAA75070 CAA78745 CAB65595 CAI95946 EAX03424 P01375 AB451492 BAG70306 AF043342 AAC03542 AF098751 AAF71992 AJ227911 AJ251878 CAB63904 AJ251879 CAB63905 AK314960 BAG37464 BC028148 AAH28148 BI908079 BP215875 CA306559 DQ891662 ABM82588 DQ894849 ABM85775 FJ795028 ACO37640 HQ201306 ADV31546 M10988 AAA61198 M35592 AAC42098 X01394 CAA25650 NM_000594 NP_000585
Function	Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:23396208}.
Subcellular Location	C-domain 2: Secreted.
Top Pathways	TNF signaling pathway, Proteoglycans in cancer, Sphingolipid signaling pathway, NOD-like receptor signaling pathway, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active cow TNF alpha full length protein - ab87904 from Abcam Category Protein Prices $315.00 Sizes 25 µg Source Yeast Species Bovine

Active human TNF alpha full length protein - ab155699 from Abcam Category Protein Prices $410.00 Sizes 100 µg Source HEK 293 cells Species Human

Active human TNF alpha full length protein - ab193885 from Abcam Category Protein Prices $176.00 Sizes 4 µg Source Mammalian Species Human

Active human TNF alpha full length protein - ab179617 from Abcam Category Protein Prices $202.00, $1,200.00 Sizes 50 µg, 500 µg Source E. coli Species Human

Active human TNF alpha full length protein - ab192134 from Abcam Category Protein Prices $192.00 Sizes 50 µg Source E. coli Species Human

Active human TNF alpha full length protein - ab83544 from Abcam Category Protein Prices $340.00 Sizes 5 µg Source HEK 293 cells Species Human

Active human TNF alpha protein fragment - ab157349 from Abcam Category Protein Prices $352.00 Sizes 50 µg Source E. coli Species Human

Active mouse TNF alpha full length protein - ab157351 from Abcam Category Protein Prices $352.00 Sizes 50 µg Source E. coli Species Mouse

Active mouse TNF alpha full length protein - ab9740 from Abcam Category Protein Prices $110.00, $257.00 Sizes 5 µg, 20 µg Source E. coli Species Mouse

Active mouse TNF alpha full length protein - ab191622 from Abcam Category Protein Prices $192.00 Sizes 20 µg Source E. coli Species Mouse

Active pig TNF alpha full length protein - ab87909 from Abcam Category Protein Prices $315.00 Sizes 25 µg Source Yeast Species Pig

Active pig TNF alpha full length protein - ab73872 from Abcam Category Protein Source E. coli Species Pig

Active rat TNF alpha full length protein - ab9756 from Abcam Category Protein Prices $110.00, $257.00 Sizes 5 µg, 20 µg Source E. coli Species Rat

Active rat TNF alpha full length protein - ab192119 from Abcam Category Protein Prices $192.00 Sizes 20 µg Source E. coli Species Rat

Active human TNF alpha full length protein - ab9642 from Abcam Category Protein Prices $110.00, $257.00 Sizes 10 µg, 50 µg Source E. coli Species Human

Dog TNF alpha full length protein - ab101330 from Abcam Category Protein Prices $252.00 Sizes 25 µg Source Yeast Species Dog

Guinea pig TNF alpha full length protein - ab117236 from Abcam Category Protein Prices $345.00 Sizes 25 µg Source Yeast Species Guinea Pig

Human TNF alpha full length protein - ab186083 from Abcam Category Protein Source E. coli Species Human

Human TNF alpha full length protein - ab82024 from Abcam Category Protein Source E. coli Species Human

Human TNF alpha full length protein - ab140754 from Abcam Category Protein Species Human

Human TNF alpha peptide - ab66578 from Abcam Category Peptide

Human TNF alpha full length protein - ab55237 from Abcam Category Protein Source E. coli Species Human

Human TNF alpha full length protein - ab167747 from Abcam Category Protein Source HEK 293 cells Species Human

Human TNF alpha protein fragment - ab186984 from Abcam Category Protein Source E. coli Species Human

Mouse TNF alpha full length protein - ab136374 from Abcam Category Protein Source Yeast Species Mouse

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