| Gene Symbol |
ALKBH2
|
| Entrez Gene |
121642
|
| Alt Symbol |
ABH2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
alkB, alkylation repair homolog 2 (E. coli)
|
| Other Description |
2OG-Fe(II) oxy DC1|DNA oxidative demethylase ALKBH2|alkylated DNA repair protein alkB homolog 2|alpha-ketoglutarate-dependent dioxygenase alkB homolog 2|oxy DC1
|
| Swissprots |
Q6NS38 A4PET2 Q5XLE3
|
| Accessions |
CAG17897 CCQ43124 EAW97845 Q6NS38 AB277859 BAF56576 AI278638 AK309062 AY754389 AAV28301 BC070489 AAH70489 BM785502 BM790974 BM820131 BU623121 CN421655 DA182735 HQ447536 ADQ32022 XM_005253835 XP_005253892 XM_005253836 XP_005253893 NM_001001655 NP_001001655 NM_001145374 NP_001138846 NM_001145375 NP_001138847 NM_001205179 NP_001192108 NM_001205180 NP_001192109
|
| Function |
Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine (in vitro). Has strong preference for double- stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517, ECO:0000269|PubMed:16174769, ECO:0000269|PubMed:18432238, ECO:0000269|PubMed:18519673}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517}. Note=Detected in replication foci during S-phase.
|
| Tissue Specificity |
Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder. {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:16174769}.
|