| Gene Symbol |
CALD1
|
| Entrez Gene |
800
|
| Alt Symbol |
CDM, H-CAD, HCAD, L-CAD, LCAD, NAG22
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
caldesmon 1
|
| Other Description |
caldesmon
|
| Swissprots |
Q13979 Q14742 Q9UD91 Q05682 Q14741 Q13978 A8K0X1
|
| Accessions |
CAJ29926 EAW83826 EAW83827 EAW83828 EAW83830 EAW83831 EAW83832 EAW83833 EAW83834 EAW83835 Q05682 AB062484 BAB93509 AF247820 AAF69498 AF315788 AI926727 AJ223812 AK021691 AK022222 AK022456 AK289686 BAF82375 AK298524 BAG60727 AK300282 BAH13250 AK304729 BAG65492 AL601004 AU134367 BC005006 AAH05006 BC014035 AAH14035 BC015839 BC040354 AAH40354 BC061926 AAH61926 BF675655 BF965359 BQ010124 BU683034 BX538339 CAD98104 BX648808 BX649088 CAI46261 CA433571 CA447404 CD359921 CK821334 CN314587 CV573441 D90452 BAA14418 D90453 BAA14419 DA323544 DA546174 DB090561 M64110 AAA35636 M83216 AAA58419 XM_006716136 XP_006716199 XM_006716139 XP_006716202 XM_011516585 XP_011514887 XR_927534 XR_927535 XR_927536 XR_927537 XR_927538 XR_927539 XR_927540 XR_927541 XR_927542 NM_004342 NP_004333 NM_033138 NP_149129 NM_033139 NP_149130 NM_033140 NP_149131 NM_033157 NP_149347
|
| Function |
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril {ECO:0000250}. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). {ECO:0000250}.
|
| Tissue Specificity |
High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular- weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
|
| Top Pathways |
Vascular smooth muscle contraction
|
